Sandbox Reserved 1683: Difference between revisions
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== Viral RNA Transcription and Translation == | == Viral RNA Transcription and Translation == | ||
Influenza A being comprised of negative-sense RNA means it cannot be immediately translated by the host, and instead the viral RNA must first be copied so that the complementary strand runs in the proper 5' to 3' direction.<ref>PMID:23009810</ref> Influenza A utilizes its viral polymerase to engage in cap-snatching in which it takes 5' capped RNA fragments from the host's capped RNAs.<ref>PMID:27396566</ref> Afterwards, the cap-binding domain rotates to insert the 3' end of the capped RNA into the active site, and NTPs enter through the entry channel as the polymerase constructs a strand complementary to the viral RNA.<ref>PMID:27396566</ref> | |||
== Conservation within Influenza A RDRP == | == Conservation within Influenza A RDRP == | ||
