Sandbox Reserved 1689: Difference between revisions
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The PB1 subunit constitutes the stereotypical right-handed model of RdRp, including the fingers, palm, and thumb of the hand. Motifs A-E are contained within the PB1 domain: motifs A, C, D, and E are all in the palm, and motifs B and F are in the fingers. The PB2 domain interacts with the PB1 thumb and C-terminus extension, conferring flexibility and stability to the overall complex. The PA domain spans the backside of PB1 and is responsible for the endonuclease activity of the RdRp. | The PB1 subunit constitutes the stereotypical right-handed model of RdRp, including the fingers, palm, and thumb of the hand. Motifs A-E are contained within the PB1 domain: motifs A, C, D, and E are all in the palm, and motifs B and F are in the fingers. The PB2 domain interacts with the PB1 thumb and C-terminus extension, conferring flexibility and stability to the overall complex. The PA domain spans the backside of PB1 and is responsible for the endonuclease activity of the RdRp. | ||
The PB2 also contains the cap-binding domain necessary for cap-snatching. PB2 recognizes host primers and captures host RNA, allowing PA's endonuclease domain to cleave primers away. | SCENE coloring different motifs | ||
SCENE | |||
The PB2 also contains the cap-binding domain necessary for cap-snatching. PB2 recognizes host primers and captures host RNA, allowing PA's endonuclease domain to cleave primers away for use with vRNA. | |||
SCENE highlighting this site | |||
</StructureSection> | </StructureSection> | ||
