Sandbox Reserved 1689: Difference between revisions

Line 7:

==IAV RNA-Dependent RNA Polymerase==

The RNA-dependent RNA polymerase (RdRp) is a critical protein complex for the replication and transcription of viral genes. This enzyme is of clinical significance in IAV because it is critical in the zoonosis of Influenza A viruses like swine flu. Because of its critical roles in viral replication and zoonosis, RdRp is the focus of much antiviral research. However, due to limited structural elucidation of the Influenza A RdRP, structural-based drug design to inhibit RdRp activity is also limited. Influenza A RdRp is also an especially difficult site for drug development because it is unique relative to other viral RdRps. Unlike many other viral RdRps, IAV RdRp must first enter the nucleus to transcribe and replicate viral genetic information as opposed to first initiating translation in the cytoplasm. To initiate transcription, primers must be taken from host RNAs through cap-snatching, wherein 5' caps are cleaved from host RNAs and transferred to viral RNA.

The RNA-dependent RNA polymerase (RdRp) is a critical protein complex for the replication and transcription of viral genes. This enzyme is of clinical significance in IAV because it is critical in the zoonosis of Influenza A viruses like swine flu. Because of its critical roles in viral replication and zoonosis, RdRp is the focus of much antiviral research. However, due to limited structural elucidation of the Influenza A RdRP, structural-based drug design to inhibit RdRp activity is also limited. Influenza A RdRp is also an especially difficult site for drug development because it is unique relative to other viral RdRps. Unlike many other viral RdRps, IAV RdRp must first enter the nucleus to transcribe and replicate viral genetic information as opposed to first initiating translation in the cytoplasm. To initiate transcription, primers must be taken from host RNAs through cap-snatching, wherein 5' caps are cleaved from host RNAs and transferred to viral RNA. Swine flu RdRp is structurally similar to other RdRps in the conservation of motifs A-E, which are conserved across all RdRps.

==Structure==

Sandbox Reserved 1689: Difference between revisions

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 7: / Line 7: @@
 ==IAV RNA-Dependent RNA Polymerase==
-The RNA-dependent RNA polymerase (RdRp) is a critical protein complex for the replication and transcription of viral genes. This enzyme is of clinical significance in IAV because it is critical in the zoonosis of Influenza A viruses like swine flu. Because of its critical roles in viral replication and zoonosis, RdRp is the focus of much antiviral research. However, due to limited structural elucidation of the Influenza A RdRP, structural-based drug design to inhibit RdRp activity is also limited. Influenza A RdRp is also an especially difficult site for drug development because it is unique relative to other viral RdRps. Unlike many other viral RdRps, IAV RdRp must first enter the nucleus to transcribe and replicate viral genetic information as opposed to first initiating translation in the cytoplasm. To initiate transcription, primers must be taken from host RNAs through cap-snatching, wherein 5' caps are cleaved from host RNAs and transferred to viral RNA.
+The RNA-dependent RNA polymerase (RdRp) is a critical protein complex for the replication and transcription of viral genes. This enzyme is of clinical significance in IAV because it is critical in the zoonosis of Influenza A viruses like swine flu. Because of its critical roles in viral replication and zoonosis, RdRp is the focus of much antiviral research. However, due to limited structural elucidation of the Influenza A RdRP, structural-based drug design to inhibit RdRp activity is also limited. Influenza A RdRp is also an especially difficult site for drug development because it is unique relative to other viral RdRps. Unlike many other viral RdRps, IAV RdRp must first enter the nucleus to transcribe and replicate viral genetic information as opposed to first initiating translation in the cytoplasm. To initiate transcription, primers must be taken from host RNAs through cap-snatching, wherein 5' caps are cleaved from host RNAs and transferred to viral RNA. Swine flu RdRp is structurally similar to other RdRps in the conservation of motifs A-E, which are conserved across all RdRps.
 ==Structure==