Signal transduction: Difference between revisions
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*[[Membrane Channels & Pumps]] | *[[Membrane Channels & Pumps]] | ||
*[[Ryanodine receptor]] | *[[Ryanodine receptor]] | ||
'''Lipid signaling:''' | |||
''Ceramide'' | |||
*[[Sphingomyelinase]] (SMase) or sphingomyelin phosphodiesterase is a hydrolase involved in sphingolipid metabolism. It catalyzes the breakdown of sphingomyelin (SM) to phosphocholine and ceramide<ref>PMID:11001563</ref>. | |||
*[[Acid-beta-glucosidase]] or '''glucosylceramidase''' is a lysozomal enzyme (EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.45 3.2.1.45]), which cleaves glucosylceramide to glucose and ceramide. It catalyzes hydrolysis of the sphingolipid, <scene name='Acid-beta-glucosidase/Cv/3'>glucosylceramide (GlcCer)</scene>, to <scene name='Acid-beta-glucosidase/Cv/2'>glucose and ceramide</scene> at the acidic pH prevailing within the lysosome. <scene name='Acid-beta-glucosidase/Cv/4'>Click here to see animation of this reaction</scene>. | |||
*The molecular function of [[galactosylceramidase]] is hydrolysis of a O-glycosyl bond to remove galactose from ceramide and other sphingolipids. | |||
''Sphingosine-1-Phosphate'' | |||
*[[Lysophosphatidic acid receptor#Sphingosine 1-Phosphate Receptor]] | |||
''Glucosylceramide'' | |||
*[[Acid-beta-glucosidase]] | |||
Phosphatidylinositol 4,5-bisphosphate (PIP2) binds to and directly activates inwardly rectifying [[potassium channels]]. Inward rectifier KCh. | |||
*[[Lysophosphatidic acid receptor]] | |||
*[[GPR40]] | |||
'''Signaling Pathways:''' | '''Signaling Pathways:''' | ||
