Sandbox Reserved 1687: Difference between revisions
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==Function of RNA-Dependent RNA Polymerase== | ==Function of RNA-Dependent RNA Polymerase== | ||
RNA-dependent RNA polymerases (RdRp) are critical to the replication of RNA viruses.<ref>DOI:10.1038/s41598-018-22328-3</ref> Due to this protein's importance in the viral life cycle, they are feasible targets for vaccine development.<ref>DOI:10.1038/s41598-018-22328-3</ref> | RNA-dependent RNA polymerases (RdRp) are critical to the replication of RNA viruses.<ref>DOI:10.1038/s41598-018-22328-3</ref> Due to this protein's importance in the viral life cycle, they are feasible targets for vaccine development.<ref>DOI:10.1038/s41598-018-22328-3</ref> Inhibition of RdRp results in the inhibition of transcription of the viral genome, ultimately resulting in no new production of virions for the virus. | ||
==Structural Features of Ebola Virus RNA-Dependent RNA Polymerase== | ==Structural Features of Ebola Virus RNA-Dependent RNA Polymerase== | ||
EBOV has a monomeric RNA-dependent RNA polymerase and as such, shares the characteristic right-hand shape of other monomeric RdRp composed of the fingertips, palm, and thumb subdomains. <ref>PMID:26397100</ref> The | EBOV has a monomeric RNA-dependent RNA polymerase and as such, shares the characteristic right-hand shape of other monomeric RdRp composed of the fingertips, palm, and thumb subdomains. <ref>PMID:26397100</ref> The fingertips subdomain is composed of residues 417-439 and 489-563, the palm subdomain is composed of residues 440-488 and 563-666, and the thumb is made up of residues 667-704.<ref>PMID:26397100</ref> | ||
==RNA Transcription and Translation== | ==RNA Transcription and Translation== | ||
