Sandbox Reserved 1687: Difference between revisions
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==Structural Features of Ebola Virus RNA-Dependent RNA Polymerase[https://swissmodel.expasy.org/interactive/7EhwKr/]== | ==Structural Features of Ebola Virus RNA-Dependent RNA Polymerase[https://swissmodel.expasy.org/interactive/7EhwKr/]== | ||
EBOV has a monomeric RNA-dependent RNA polymerase and as such, shares the characteristic <scene name='89/891377/Rh_shape/1'>right-hand shape</scene> of other monomeric RdRp composed of the fingertips, palm, and thumb subdomains. <ref>PMID:26397100</ref> The <scene name='89/891377/Fingertips_subdomain_2/4'>fingertips subdomain</scene> is composed of residues 417-439 and 489-563, the <scene name='89/891377/Palm_subdomain_1/5'>palm subdomain</scene> is composed of residues 440-488 and 563-666, and the <scene name='89/891377/Thumb_subdomain/1'>thumb</scene> is made up of residues 667-704.<ref>PMID:26397100</ref> | EBOV has a monomeric RNA-dependent RNA polymerase and as such, shares the characteristic <scene name='89/891377/Rh_shape/1'>right-hand shape</scene> of other monomeric RdRp composed of the fingertips, palm, and thumb subdomains. <ref>PMID:26397100</ref> The <scene name='89/891377/Fingertips_subdomain_2/4'>fingertips subdomain</scene> is composed of residues 417-439 and 489-563, the <scene name='89/891377/Palm_subdomain_1/5'>palm subdomain</scene> is composed of residues 440-488 and 563-666, and the <scene name='89/891377/Thumb_subdomain/1'>thumb</scene> is made up of residues 667-704.<ref>PMID:26397100</ref> The highly conserved motifs A-E were identified in the palm subdomain of the EBOV RdRp, but motifs F and G, which are not part of the active site, were not identified.<ref>PMID:26397100</ref> | ||
==RNA Transcription and Translation== | ==RNA Transcription and Translation== | ||
