3ld1: Difference between revisions

<table><tr><td colspan='2'>[[3ld1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Avian_infectious_bronchitis_virus_(strain_m41) Avian infectious bronchitis virus (strain m41)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LD1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LD1 FirstGlance]. <br>

</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">1a, 1ab ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11127 Avian infectious bronchitis virus (strain M41)])</td></tr>

[[https://www.uniprot.org/uniprot/R1A_IBVM R1A_IBVM]] The papain-like proteinase (PL-PRO) is responsible for the cleavages located at the N-terminus of replicase polyprotein. Activity of PL-PRO is dependent on zinc (By similarity).  The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK. Also contains an ADP-ribose-1''-phosphate (ADRP)-binding function (By similarity).  The peptide p16 might be involved in the EGF signaling pathway (By similarity).  Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter (By similarity).  Nsp9 is a ssRNA-binding protein (By similarity).  

[[Category: Bartlam, M]]

[[Category: Chen, C]]

[[Category: Cong, L]]

[[Category: Fu, J]]

[[Category: Rao, Z]]

[[Category: Tang, H]]

[[Category: Wei, L]]

[[Category: Xu, Y]]

[[Category: Yang, A]]

[[Category: Zinc-finger]]