1vf7: Difference between revisions

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<StructureSection load='1vf7' size='340' side='right'caption='[[1vf7]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='1vf7' size='340' side='right'caption='[[1vf7]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1vf7]] is a 13 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VF7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VF7 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1vf7]] is a 13 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VF7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VF7 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vf7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vf7 OCA], [https://pdbe.org/1vf7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vf7 RCSB], [https://www.ebi.ac.uk/pdbsum/1vf7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vf7 ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vf7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vf7 OCA], [https://pdbe.org/1vf7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vf7 RCSB], [https://www.ebi.ac.uk/pdbsum/1vf7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vf7 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/MEXA_PSEAE MEXA_PSEAE]] The periplasmic linker component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Required for assembly of the MexA/MexB/OprM complex. Implicated in the secretion of the siderophore pyoverdine.<ref>PMID:8226684</ref> <ref>PMID:8540696</ref> <ref>PMID:9603892</ref>  The ability to export antibiotics and solvents is dramatically decreased in the presence of the proton conductor carbonyl cyanide m-chlorophenylhydrazone (CCCP), showing that an energized inner membrane is required for efflux. It is thought that the MexB subunit is a proton antiporter.<ref>PMID:8226684</ref> <ref>PMID:8540696</ref> <ref>PMID:9603892</ref>
[https://www.uniprot.org/uniprot/MEXA_PSEAE MEXA_PSEAE] The periplasmic linker component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Required for assembly of the MexA/MexB/OprM complex. Implicated in the secretion of the siderophore pyoverdine.<ref>PMID:8226684</ref> <ref>PMID:8540696</ref> <ref>PMID:9603892</ref>  The ability to export antibiotics and solvents is dramatically decreased in the presence of the proton conductor carbonyl cyanide m-chlorophenylhydrazone (CCCP), showing that an energized inner membrane is required for efflux. It is thought that the MexB subunit is a proton antiporter.<ref>PMID:8226684</ref> <ref>PMID:8540696</ref> <ref>PMID:9603892</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Akama, H]]
[[Category: Pseudomonas aeruginosa]]
[[Category: Kashiwagi, S]]
[[Category: Akama H]]
[[Category: Matsuura, T]]
[[Category: Kashiwagi S]]
[[Category: Nakae, T]]
[[Category: Matsuura T]]
[[Category: Nakagawa, A]]
[[Category: Nakae T]]
[[Category: Tsukihara, T]]
[[Category: Nakagawa A]]
[[Category: Yoneyama, H]]
[[Category: Tsukihara T]]
[[Category: Alpha hairpin]]
[[Category: Yoneyama H]]
[[Category: Beta barrel]]
[[Category: Membrane protein]]
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