How to predict structures with AlphaFold: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Eric Martz (talk | contribs) |
Eric Martz (talk | contribs) |
||
| Line 33: | Line 33: | ||
Each predicted model has an average estimated reliability (pLDDT). >90 is likely accurate; <70 is low confidence. For more about interpreting these values, please see the [https://alphafold.ebi.ac.uk/faq AlphaFold Database FAQ]. | Each predicted model has an average estimated reliability (pLDDT). >90 is likely accurate; <70 is low confidence. For more about interpreting these values, please see the [https://alphafold.ebi.ac.uk/faq AlphaFold Database FAQ]. | ||
[[FirstGlance in Jmol]] version 3.7 (when released) will automatically color uploaded AlphaFold models by estimated reliability per residue. | |||
Some models have high confidence in a folded [[domain]], and low confidence in a segment that is not part of a compact domain. Low-confidence segments may be [[intrinsically disordered]]. It is useful to compare [[Intrinsically_Disordered_Protein#Protein_disorder_predictors|predictions of disorder]] with AlphaFold reliability estimates. | |||
You may be interested to note the number of recycles required for each model to converge to the specified tolerance. These numbers are not captured in the downloaded zip file. | You may be interested to note the number of recycles required for each model to converge to the specified tolerance. These numbers are not captured in the downloaded zip file. | ||
