1fh0: Difference between revisions

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[[Image:1fh0.jpg|left|200px]]
{{Seed}}
[[Image:1fh0.png|left|200px]]


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{{STRUCTURE_1fh0|  PDB=1fh0  |  SCENE=  }}  
{{STRUCTURE_1fh0|  PDB=1fh0  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF HUMAN CATHEPSIN V COMPLEXED WITH AN IRREVERSIBLE VINYL SULFONE INHIBITOR'''
===CRYSTAL STRUCTURE OF HUMAN CATHEPSIN V COMPLEXED WITH AN IRREVERSIBLE VINYL SULFONE INHIBITOR===




==Overview==
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Cathepsin V is a lysosomal cysteine protease that is expressed in the thymus, testis and corneal epithelium. We have determined the 1.6 A resolution crystal structure of human cathepsin V associated with an irreversible vinyl sulfone inhibitor. The fold of this enzyme is similar to the fold adopted by other members of the papain superfamily of cysteine proteases. This study provides a framework for understanding the structural basis for cathepsin V's activity and will aid in the design of inhibitors of this enzyme. A comparison of cathepsin V's active site with the active sites of related proteases revealed a number of differences, especially in the S2 and S3 subsites, that could be exploited in identifying specific cathepsin V inhibitors or in identifying inhibitors of other cysteine proteases that would be selective against cathepsin V.
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{{ABSTRACT_PUBMED_11027133}}


==About this Structure==
==About this Structure==
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[[Category: Papain]]
[[Category: Papain]]
[[Category: Protease]]
[[Category: Protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:14:10 2008''

Revision as of 00:14, 1 July 2008

File:1fh0.png

Template:STRUCTURE 1fh0

CRYSTAL STRUCTURE OF HUMAN CATHEPSIN V COMPLEXED WITH AN IRREVERSIBLE VINYL SULFONE INHIBITOR

Template:ABSTRACT PUBMED 11027133

About this Structure

1FH0 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human cathepsin V., Somoza JR, Zhan H, Bowman KK, Yu L, Mortara KD, Palmer JT, Clark JM, McGrath ME, Biochemistry. 2000 Oct 17;39(41):12543-51. PMID:11027133

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