1fgz: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
Line 1: Line 1:
[[Image:1fgz.jpg|left|200px]]
{{Seed}}
[[Image:1fgz.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1fgz|  PDB=1fgz  |  SCENE=  }}  
{{STRUCTURE_1fgz|  PDB=1fgz  |  SCENE=  }}  


'''GRP1 PH DOMAIN (UNLIGANDED)'''
===GRP1 PH DOMAIN (UNLIGANDED)===




==Overview==
<!--
Lipid second messengers generated by phosphoinositide (PI) 3-kinases regulate diverse cellular functions through interaction with pleckstrin homology (PH) domains in modular signaling proteins. The PH domain of Grp1, a PI 3-kinase-activated exchange factor for Arf GTPases, selectively binds phosphatidylinositol 3,4,5-trisphosphate with high affinity. We have determined the structure of the Grp1 PH domain in the unliganded form and bound to inositol 1,3,4,5-tetraphosphate. A novel mode of phosphoinositide recognition involving a 20-residue insertion within the beta6/beta7 loop explains the unusually high specificity of the Grp1 PH domain and the promiscuous 3-phosphoinositide binding typical of several PH domains including that of protein kinase B. When compared to other PH domains, general determinants of 3-phosphoinositide recognition and specificity can be deduced.
The line below this paragraph, {{ABSTRACT_PUBMED_10983985}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 10983985 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_10983985}}


==About this Structure==
==About this Structure==
Line 30: Line 34:
[[Category: Lietzke, S E.]]
[[Category: Lietzke, S E.]]
[[Category: Ph domain]]
[[Category: Ph domain]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:18:52 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:14:02 2008''
Retrieved from "https://proteopedia.org/1fgz"