1fh5: Difference between revisions

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[[Image:1fh5.~~gif~~|left|200px]]

[[Image:1fh5.png|left|200px]]

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~~'''~~CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF THE MONOCLONAL ANTIBODY MAK33~~'''~~

===CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF THE MONOCLONAL ANTIBODY MAK33===

~~==Overview==~~

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The ~~Fab fragment of the murine monoclonal antibody~~, ~~MAK33~~, ~~directed against human creatine kinase of~~ the ~~muscle-type, was crystallized and~~ the ~~three-dimensional structure was determined to 2~~.~~9 A~~. The antigen-binding surface of MAK33 shows a convex overall shape typical for immunoglobulins binding large antigens. The structure allows us to analyze the environment of cis-prolyl-peptide bonds whose isomerization is ~~of key importance in~~ the ~~folding process~~. These residues seem to be involved with not only domain stability but also seem to play a role in the association of heavy and light chains, reinforcing the importance of beta-strand recognition in antibody assembly. The structure also allows the localization of segments of primary sequence postulated to represent binding sites for the ER-~~specific chaperone BiP within the context of the entire Fab fragment. These sequences are found primarily in beta~~-~~strands that are necessary for interactions between the individual domains.~~

The line below this paragraph, {{ABSTRACT_PUBMED_11036070}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 11036070 is the PubMed ID number.

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==About this Structure==

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[[Category: Crystal structure]]

[[Category: Fab]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ ~~2 16~~:19:07 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:14:32 2008''

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-[[Image:1fh5.gif|left|200px]]
+{{Seed}}
+[[Image:1fh5.png|left|200px]]
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 {{STRUCTURE_1fh5|  PDB=1fh5  |  SCENE=  }}
-'''CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF THE MONOCLONAL ANTIBODY MAK33'''
+===CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF THE MONOCLONAL ANTIBODY MAK33===
-==Overview==
+<!--
-The Fab fragment of the murine monoclonal antibody, MAK33, directed against human creatine kinase of the muscle-type, was crystallized and the three-dimensional structure was determined to 2.9 A. The antigen-binding surface of MAK33 shows a convex overall shape typical for immunoglobulins binding large antigens. The structure allows us to analyze the environment of cis-prolyl-peptide bonds whose isomerization is of key importance in the folding process. These residues seem to be involved with not only domain stability but also seem to play a role in the association of heavy and light chains, reinforcing the importance of beta-strand recognition in antibody assembly. The structure also allows the localization of segments of primary sequence postulated to represent binding sites for the ER-specific chaperone BiP within the context of the entire Fab fragment. These sequences are found primarily in beta-strands that are necessary for interactions between the individual domains.
+The line below this paragraph, {{ABSTRACT_PUBMED_11036070}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 11036070 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_11036070}}
 ==About this Structure==
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 [[Category: Crystal structure]]
 [[Category: Fab]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 16:19:07 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 03:14:32 2008''