2nww: Difference between revisions
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<StructureSection load='2nww' size='340' side='right'caption='[[2nww]], [[Resolution|resolution]] 3.20Å' scene=''> | <StructureSection load='2nww' size='340' side='right'caption='[[2nww]], [[Resolution|resolution]] 3.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2nww]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2nww]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NWW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NWW FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TB1:(3S)-3-(BENZYLOXY)-L-ASPARTIC+ACID'>TB1</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nww OCA], [https://pdbe.org/2nww PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nww RCSB], [https://www.ebi.ac.uk/pdbsum/2nww PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nww ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nww OCA], [https://pdbe.org/2nww PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nww RCSB], [https://www.ebi.ac.uk/pdbsum/2nww PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nww ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/GLT_PYRHO GLT_PYRHO] Sodium-dependent, high-affinity amino acid transporter that mediates aspartate uptake (PubMed:17435767, PubMed:19380583, PubMed:17230192, Ref.11). Has only very low glutamate transport activity (PubMed:19380583, PubMed:17230192). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions, resulting in electrogenic transport (PubMed:17435767, PubMed:19380583, Ref.11). Na(+) binding enhances the affinity for aspartate (PubMed:19380583, Ref.11). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:17435767). In contrast to mammalian homologs, transport does not depend on pH or K(+) ions (PubMed:19380583).<ref>PMID:17230192</ref> <ref>PMID:17435767</ref> <ref>PMID:19380583</ref> [PDB:4P19] | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Boudker | [[Category: Pyrococcus horikoshii]] | ||
[[Category: Gouaux | [[Category: Boudker O]] | ||
[[Category: Ryan | [[Category: Gouaux E]] | ||
[[Category: Shimamoto | [[Category: Ryan R]] | ||
[[Category: Yernool | [[Category: Shimamoto K]] | ||
[[Category: Yernool D]] | |||
