3fn1: Difference between revisions

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<StructureSection load='3fn1' size='340' side='right'caption='[[3fn1]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='3fn1' size='340' side='right'caption='[[3fn1]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3fn1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FN1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FN1 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3fn1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FN1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FN1 FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">E1C, UBA3, UBE1C ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), NCE2, UBE2F ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fn1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fn1 OCA], [https://pdbe.org/3fn1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fn1 RCSB], [https://www.ebi.ac.uk/pdbsum/3fn1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fn1 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fn1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fn1 OCA], [https://pdbe.org/3fn1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fn1 RCSB], [https://www.ebi.ac.uk/pdbsum/3fn1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fn1 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/UBA3_HUMAN UBA3_HUMAN]] Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression.<ref>PMID:10207026</ref> <ref>PMID:9694792</ref> <ref>PMID:12740388</ref> [[https://www.uniprot.org/uniprot/UBE2F_HUMAN UBE2F_HUMAN]] Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5.
[https://www.uniprot.org/uniprot/UBA3_HUMAN UBA3_HUMAN] Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression.<ref>PMID:10207026</ref> <ref>PMID:9694792</ref> <ref>PMID:12740388</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Ayrault, O]]
[[Category: Ayrault O]]
[[Category: Borg, L A]]
[[Category: Borg LA]]
[[Category: Duda, D M]]
[[Category: Duda DM]]
[[Category: Huang, D T]]
[[Category: Huang DT]]
[[Category: Hunt, H W]]
[[Category: Hunt HW]]
[[Category: Murray, P J]]
[[Category: Murray PJ]]
[[Category: Neale, G]]
[[Category: Neale G]]
[[Category: Roussel, M F]]
[[Category: Roussel MF]]
[[Category: Schulman, B A]]
[[Category: Schulman BA]]
[[Category: Scott, D C]]
[[Category: Scott DC]]
[[Category: Taherbhoy, A M]]
[[Category: Taherbhoy AM]]
[[Category: Atp-binding]]
[[Category: Cell cycle]]
[[Category: Ligase]]
[[Category: Nucleotide-binding]]
[[Category: Ubl conjugation pathway]]
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