2cd2: Difference between revisions

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<StructureSection load='2cd2' size='340' side='right'caption='[[2cd2]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='2cd2' size='340' side='right'caption='[[2cd2]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2cd2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pneca Pneca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CD2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CD2 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2cd2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pneumocystis_carinii Pneumocystis carinii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CD2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CD2 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FOL:FOLIC+ACID'>FOL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1cd2|1cd2]], [[3cd2|3cd2]], [[4cd2|4cd2]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FOL:FOLIC+ACID'>FOL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cd2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cd2 OCA], [https://pdbe.org/2cd2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cd2 RCSB], [https://www.ebi.ac.uk/pdbsum/2cd2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cd2 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cd2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cd2 OCA], [https://pdbe.org/2cd2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cd2 RCSB], [https://www.ebi.ac.uk/pdbsum/2cd2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cd2 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/DYR_PNECA DYR_PNECA]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.  
[https://www.uniprot.org/uniprot/DYR_PNECA DYR_PNECA] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Dihydrofolate reductase]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Pneca]]
[[Category: Pneumocystis carinii]]
[[Category: Cody, V]]
[[Category: Cody V]]
[[Category: Galitsky, N]]
[[Category: Galitsky N]]
[[Category: Luft, J]]
[[Category: Luft J]]
[[Category: Pangborn, W]]
[[Category: Pangborn W]]
[[Category: Queener, S]]
[[Category: Queener S]]
[[Category: Rak, D]]
[[Category: Rak D]]
[[Category: Folate]]
[[Category: Nadph]]
[[Category: Oxido-reductase]]
[[Category: Oxidoreductase]]
Retrieved from "https://proteopedia.org/2cd2"