2vg0: Difference between revisions

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<StructureSection load='2vg0' size='340' side='right'caption='[[2vg0]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
<StructureSection load='2vg0' size='340' side='right'caption='[[2vg0]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2vg0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VG0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VG0 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2vg0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VG0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VG0 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GPP:GERANYL+DIPHOSPHATE'>GPP</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2vfw|2vfw]], [[2vg1|2vg1]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GPP:GERANYL+DIPHOSPHATE'>GPP</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/(2Z,6E)-farnesyl_diphosphate_synthase (2Z,6E)-farnesyl diphosphate synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.68 2.5.1.68] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vg0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vg0 OCA], [https://pdbe.org/2vg0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vg0 RCSB], [https://www.ebi.ac.uk/pdbsum/2vg0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vg0 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vg0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vg0 OCA], [https://pdbe.org/2vg0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vg0 RCSB], [https://www.ebi.ac.uk/pdbsum/2vg0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vg0 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/ZFPP_MYCTU ZFPP_MYCTU]] Catalyzes the condensation of only one isopentenyl pyrophosphate (IPP) unit in the cis configuration to E-geranyl diphosphate (E-GPP) generating the 15 carbon product (2Z,6E)-farnesyl diphosphate (Z-FPP or EZ-FPP). Z-FPP is the precursor of decaprenyl diphosphate, which has a central role in the biosynthesis of the mycobacterial cell wall.<ref>PMID:11004176</ref> <ref>PMID:10816587</ref> <ref>PMID:11152452</ref>
[https://www.uniprot.org/uniprot/ZFPP_MYCTU ZFPP_MYCTU] Catalyzes the condensation of only one isopentenyl pyrophosphate (IPP) unit in the cis configuration to E-geranyl diphosphate (E-GPP) generating the 15 carbon product (2Z,6E)-farnesyl diphosphate (Z-FPP or EZ-FPP). Z-FPP is the precursor of decaprenyl diphosphate, which has a central role in the biosynthesis of the mycobacterial cell wall.<ref>PMID:11004176</ref> <ref>PMID:10816587</ref> <ref>PMID:11152452</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Dong, C]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Naismith, J H]]
[[Category: Dong C]]
[[Category: Wang, W]]
[[Category: Naismith JH]]
[[Category: Cell shape]]
[[Category: Wang W]]
[[Category: Cell wall biogenesis/degradation]]
[[Category: Peptidoglycan synthesis]]
[[Category: Prenyltransferase]]
[[Category: Secreted]]
[[Category: Transferase]]
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