2vw8: Difference between revisions

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<StructureSection load='2vw8' size='340' side='right'caption='[[2vw8]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
<StructureSection load='2vw8' size='340' side='right'caption='[[2vw8]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2vw8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VW8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VW8 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2vw8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VW8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VW8 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vw8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vw8 OCA], [https://pdbe.org/2vw8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vw8 RCSB], [https://www.ebi.ac.uk/pdbsum/2vw8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vw8 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vw8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vw8 OCA], [https://pdbe.org/2vw8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vw8 RCSB], [https://www.ebi.ac.uk/pdbsum/2vw8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vw8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PQSE_PSEAE PQSE_PSEAE] Required for the biosynthesis of the quorum-sensing signaling molecules 2-heptyl-4(1H)-quinolone (HHQ) and 2-heptyl-3-hydroxy-4(1H)-quinolone (Pseudomonas quinolone signal or PQS), which are important for biofilm formation and virulence. Catalyzes the hydrolysis of the intermediate 2-aminobenzoylacetyl-CoA (2-ABA-CoA) to form 2-aminobenzoylacetate (2-ABA), the precursor of HHQ. In vitro, can also hydrolyze other substrates such as S-ethyl-acetothioacetate and acetoacetyl-CoA, but is inactive against anthraniloyl-CoA, malonyl-CoA and octanoyl-CoA (PubMed:25960261, PubMed:27082157). Beyond its thioesterase function, is involved in the regulation of diverse genes coding for key virulence determinants and biofilm development (PubMed:27851827).<ref>PMID:25960261</ref> <ref>PMID:27082157</ref> <ref>PMID:27851827</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Pseae]]
[[Category: Pseudomonas aeruginosa PAO1]]
[[Category: Carter, L G]]
[[Category: Carter LG]]
[[Category: Johnson, K A]]
[[Category: Johnson KA]]
[[Category: Liu, H]]
[[Category: Liu H]]
[[Category: Mcmahon, S A]]
[[Category: Mcmahon SA]]
[[Category: Naismith, J H]]
[[Category: Naismith JH]]
[[Category: Oke, M]]
[[Category: Oke M]]
[[Category: White, M F]]
[[Category: White MF]]
[[Category: Quinolone signal response protein]]
[[Category: Signaling protein]]
[[Category: Sspf]]
Retrieved from "https://proteopedia.org/2vw8"