Sandbox Reserved 1683: Difference between revisions
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Motifs I-IV of the PB1 subunit are all heavily conserved as they play a significant role in the replicative capabilities of the Influenza A RDRP.<ref>PMID:22615752</ref> | Motifs I-IV of the PB1 subunit are all heavily conserved as they play a significant role in the replicative capabilities of the Influenza A RDRP.<ref>PMID:22615752</ref> | ||
== Conclusion | == Conclusion == | ||
The Influenza A viral RNA single-strand segments are negative-sense, and so they cannot be immediately read by the host cell, and therefore require transcription by the Influenza A RDRP into positive-sense RNA.<ref>PMID:20027280</ref> Only after transcription to single-stranded positive-sense RNA, which is essentially mRNA, can the RNA be translated into viral proteins which can carry on the viral lifecycle. Therefore, knowledge of the Influenza A RDRP is of utmost importance, as novel treatments can be designed that inhibit the RDRP and therefore prevent the virus from spreading after initial entry into the cell. | |||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
