7dou: Difference between revisions
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==Trimeric cement protein structure of Helicobacter pylori bacteriophage KHP40== | ==Trimeric cement protein structure of Helicobacter pylori bacteriophage KHP40== | ||
<StructureSection load='7dou' size='340' side='right'caption='[[7dou]]' scene=''> | <StructureSection load='7dou' size='340' side='right'caption='[[7dou]], [[Resolution|resolution]] 3.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DOU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DOU FirstGlance]. <br> | <table><tr><td colspan='2'>[[7dou]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_phage_khp40 Helicobacter phage khp40]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DOU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DOU FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dou OCA], [https://pdbe.org/7dou PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dou RCSB], [https://www.ebi.ac.uk/pdbsum/7dou PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dou ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dou OCA], [https://pdbe.org/7dou PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dou RCSB], [https://www.ebi.ac.uk/pdbsum/7dou PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dou ProSAT]</span></td></tr> | ||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The acid-stable capsid structures of Helicobacter pylori phages KHP30 and KHP40 are solved at 2.7 and 3.0 A resolutions by cryoelectron microscopy, respectively. The capsids have icosahedral T = 9 symmetry and consist of each 540 copies of 2 structural proteins, a major capsid protein, and a cement protein. The major capsid proteins form 12 pentagonal capsomeres occupying icosahedral vertexes and 80 hexagonal capsomeres located at icosahedral faces and edges. The major capsid protein has a unique protruding loop extending to the neighboring subunit that stabilizes hexagonal capsomeres. Furthermore, the capsid is decorated with trimeric cement proteins with a jelly roll motif. The cement protein trimer sits on the quasi-three-fold axis formed by three major capsid protein capsomeres, thereby enhancing the particle stability by connecting these capsomeres. Sequence and structure comparisons between the related Helicobacter pylori phages suggest a possible mechanism of phage adaptation to the human gastric environment. | |||
Acid-stable capsid structure of Helicobacter pylori bacteriophage KHP30 by single-particle cryoelectron microscopy.,Kamiya R, Uchiyama J, Matsuzaki S, Murata K, Iwasaki K, Miyazaki N Structure. 2021 Sep 27. pii: S0969-2126(21)00329-4. doi:, 10.1016/j.str.2021.09.001. PMID:34597601<ref>PMID:34597601</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 7dou" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Helicobacter phage khp40]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Iwasaki K]] | [[Category: Iwasaki, K]] | ||
[[Category: Kamiya R]] | [[Category: Kamiya, R]] | ||
[[Category: Matsuzaki S]] | [[Category: Matsuzaki, S]] | ||
[[Category: Miyazaki N]] | [[Category: Miyazaki, N]] | ||
[[Category: Murata K]] | [[Category: Murata, K]] | ||
[[Category: Uchiyama J]] | [[Category: Uchiyama, J]] | ||
[[Category: Capsid]] | |||
[[Category: Cryoem]] | |||
[[Category: Phage]] | |||
[[Category: Phage head]] | |||
[[Category: Virus]] | |||
