1fjh: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
Line 1: Line 1:
[[Image:1fjh.jpg|left|200px]]
{{Seed}}
[[Image:1fjh.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1fjh|  PDB=1fjh  |  SCENE=  }}  
{{STRUCTURE_1fjh|  PDB=1fjh  |  SCENE=  }}  


'''THE CRYSTAL STRUCTURE OF 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE FROM COMAMONAS TESTOSTERONI, A MEMBER OF THE SHORT CHAIN DEHYDROGENASE/REDUCTASE FAMILY'''
===THE CRYSTAL STRUCTURE OF 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE FROM COMAMONAS TESTOSTERONI, A MEMBER OF THE SHORT CHAIN DEHYDROGENASE/REDUCTASE FAMILY===




==Overview==
<!--
The crystal structure of 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni (3alpha-HSDH) as well as the structure of its binary complex with NAD(+) have been solved at 1.68-A and 1.95-A resolution, respectively. The enzyme is a member of the short chain dehydrogenase/reductase (SDR) family. Accordingly, the active center and the conformation of the bound nucleotide cofactor closely resemble those of other SDRs. The crystal structure reveals one homodimer per asymmetric unit representing the physiologically active unity. Dimerization takes place via an interface essentially built-up by helix alphaG and strand betaG of each subunit. So far this type of intermolecular contact has exclusively been observed in homotetrameric SDRs but never in the structure of a homodimeric SDR. The formation of a tetramer is blocked in 3alpha-HSDH by the presence of a predominantly alpha-helical subdomain which is missing in all other SDRs of known structure.
The line below this paragraph, {{ABSTRACT_PUBMED_11007791}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 11007791 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_11007791}}


==About this Structure==
==About this Structure==
Line 36: Line 40:
[[Category: Steroid]]
[[Category: Steroid]]
[[Category: Xenobiotic]]
[[Category: Xenobiotic]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:24:00 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:21:47 2008''
Retrieved from "https://proteopedia.org/1fjh"