1o5f: Difference between revisions

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<StructureSection load='1o5f' size='340' side='right'caption='[[1o5f]], [[Resolution|resolution]] 1.78&Aring;' scene=''>
<StructureSection load='1o5f' size='340' side='right'caption='[[1o5f]], [[Resolution|resolution]] 1.78&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1o5f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O5F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1O5F FirstGlance]. <br>
<table><tr><td colspan='2'>[[1o5f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O5F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1O5F FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CR9:2-{5-[AMINO(IMINIO)METHYL]-6-FLUORO-1H-BENZIMIDAZOL-2-YL}-6-[(2-METHYLCYCLOHEXYL)OXY]BENZENOLATE'>CR9</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.78&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1p57|1p57]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CR9:2-{5-[AMINO(IMINIO)METHYL]-6-FLUORO-1H-BENZIMIDAZOL-2-YL}-6-[(2-METHYLCYCLOHEXYL)OXY]BENZENOLATE'>CR9</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HPN OR TMPRSS1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1o5f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o5f OCA], [https://pdbe.org/1o5f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1o5f RCSB], [https://www.ebi.ac.uk/pdbsum/1o5f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1o5f ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1o5f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o5f OCA], [https://pdbe.org/1o5f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1o5f RCSB], [https://www.ebi.ac.uk/pdbsum/1o5f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1o5f ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/HEPS_HUMAN HEPS_HUMAN]] Plays an essential role in cell growth and maintenance of cell morphology. May mediate the activating cleavage of HGF and MST1/HGFL.<ref>PMID:21875933</ref> <ref>PMID:15839837</ref>
[https://www.uniprot.org/uniprot/HEPS_HUMAN HEPS_HUMAN] Plays an essential role in cell growth and maintenance of cell morphology. May mediate the activating cleavage of HGF and MST1/HGFL.<ref>PMID:21875933</ref> <ref>PMID:15839837</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Chan, H]]
[[Category: Chan H]]
[[Category: Gjerstad, E]]
[[Category: Gjerstad E]]
[[Category: Ho, J D]]
[[Category: Ho JD]]
[[Category: Janc, J W]]
[[Category: Janc JW]]
[[Category: Katz, B A]]
[[Category: Katz BA]]
[[Category: Luong, C]]
[[Category: Luong C]]
[[Category: Mackman, R L]]
[[Category: Mackman RL]]
[[Category: McGrath, M E]]
[[Category: McGrath ME]]
[[Category: Mortara, K]]
[[Category: Mortara K]]
[[Category: Somoza, J R]]
[[Category: Somoza JR]]
[[Category: Sprengeler, P A]]
[[Category: Sprengeler PA]]
[[Category: Tang, J]]
[[Category: Tang J]]
[[Category: Verner, E]]
[[Category: Verner E]]
[[Category: Williams, S R]]
[[Category: Williams SR]]
[[Category: Young, W B]]
[[Category: Young WB]]
[[Category: Conserved water displacement hydrogen bond deficit]]
[[Category: Factor viia]]
[[Category: Hepsin]]
[[Category: Hydrolase]]
[[Category: S1 site]]
[[Category: Scavenger receptor cysteine-rich domain]]
[[Category: Selectivity]]
[[Category: Serine protease]]
[[Category: Serine protease ala190 upa]]
[[Category: Srcr]]
[[Category: Thrombin]]
[[Category: Trypsin]]
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