1vl9: Difference between revisions

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<StructureSection load='1vl9' size='340' side='right'caption='[[1vl9]], [[Resolution|resolution]] 0.97&Aring;' scene=''>
<StructureSection load='1vl9' size='340' side='right'caption='[[1vl9]], [[Resolution|resolution]] 0.97&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1vl9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VL9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VL9 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1vl9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VL9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VL9 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.97&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PLA2G1B ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vl9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vl9 OCA], [https://pdbe.org/1vl9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vl9 RCSB], [https://www.ebi.ac.uk/pdbsum/1vl9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vl9 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vl9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vl9 OCA], [https://pdbe.org/1vl9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vl9 RCSB], [https://www.ebi.ac.uk/pdbsum/1vl9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vl9 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/PA21B_BOVIN PA21B_BOVIN]] PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.  
[https://www.uniprot.org/uniprot/PA21B_BOVIN PA21B_BOVIN] PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bovin]]
[[Category: Bos taurus]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Dauter, M]]
[[Category: Dauter M]]
[[Category: Dauter, Z]]
[[Category: Dauter Z]]
[[Category: Gayathri, D]]
[[Category: Gayathri D]]
[[Category: Poi, M J]]
[[Category: Poi M-J]]
[[Category: Rajakannan, V]]
[[Category: Rajakannan V]]
[[Category: Sekar, K]]
[[Category: Sekar K]]
[[Category: Tsai, M D]]
[[Category: Tsai M-D]]
[[Category: Velmurugan, D]]
[[Category: Velmurugan D]]
[[Category: Alpha helix]]
[[Category: Beta sheet]]
[[Category: Calcium ion]]
[[Category: Hydrolase]]
[[Category: Triple mutant]]

Latest revision as of 00:04, 28 December 2023

Atomic resolution (0.97A) structure of the triple mutant (K53,56,121M) of bovine pancreatic phospholipase A2

1vl9, resolution 0.97Å

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