1fkn: Difference between revisions

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[[Image:1fkn.~~gif~~|left|200px]]

[[Image:1fkn.png|left|200px]]

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~~==Overview==~~

Memapsin 2 (beta-secretase) is a membrane-associated aspartic protease involved in the production of beta-amyloid peptide in Alzheimer's disease and is a major target for drug design. We determined the crystal structure of the protease domain of human memapsin 2 complexed to an eight-residue inhibitor at 1.9 angstrom resolution. The active site of memapsin 2 is more open and less hydrophobic than that of other human aspartic proteases. The subsite locations from S4 to S2' are well defined. A kink of the inhibitor chain at P2' and the change of chain direction of P3' and P4' may be mimicked to provide inhibitor selectivity.

==About this Structure==

1FKN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1FKN with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb79_1.html Amyloid-beta Precursor Protein]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FKN OCA].

~~==Reference==~~

Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor., Hong L, Koelsch G, Lin X, Wu S, Terzyan S, Ghosh AK, Zhang XC, Tang J, Science. 2000 Oct 6;290(5489):150-3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11021803 11021803]

[[Category: Amyloid-beta Precursor Protein]]

[[Category: Homo sapiens]]

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[[Category: Beta-secretase]]

[[Category: Memapsin 2]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May 2 16~~:26:16 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:21:55 2008''

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-[[Image:1fkn.gif|left|200px]]
+[[Image:1fkn.png|left|200px]]
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-==Overview==
+{{ABSTRACT_11021803}}
-Memapsin 2 (beta-secretase) is a membrane-associated aspartic protease involved in the production of beta-amyloid peptide in Alzheimer's disease and is a major target for drug design. We determined the crystal structure of the protease domain of human memapsin 2 complexed to an eight-residue inhibitor at 1.9 angstrom resolution. The active site of memapsin 2 is more open and less hydrophobic than that of other human aspartic proteases. The subsite locations from S4 to S2' are well defined. A kink of the inhibitor chain at P2' and the change of chain direction of P3' and P4' may be mimicked to provide inhibitor selectivity.
 ==About this Structure==
 FKN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1FKN with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb79_1.html Amyloid-beta Precursor Protein]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FKN OCA].
-==Reference==
-Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor., Hong L, Koelsch G, Lin X, Wu S, Terzyan S, Ghosh AK, Zhang XC, Tang J, Science. 2000 Oct 6;290(5489):150-3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11021803 11021803]
 [[Category: Amyloid-beta Precursor Protein]]
 [[Category: Homo sapiens]]
@@ Line 36: / Line 32: @@
 [[Category: Beta-secretase]]
 [[Category: Memapsin 2]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 16:26:16 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:21:55 2008''