1fkr: Difference between revisions

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[[Image:1fkr.gif|left|200px]]
{{Seed}}
[[Image:1fkr.png|left|200px]]


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{{STRUCTURE_1fkr|  PDB=1fkr  |  SCENE=  }}  
{{STRUCTURE_1fkr|  PDB=1fkr  |  SCENE=  }}  


'''SOLUTION STRUCTURE OF FKBP, A ROTAMASE ENZYME AND RECEPTOR FOR FK506 AND RAPAMYCIN'''
===SOLUTION STRUCTURE OF FKBP, A ROTAMASE ENZYME AND RECEPTOR FOR FK506 AND RAPAMYCIN===




==Overview==
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Immunophilins, when complexed to immunosuppressive ligands, appear to inhibit signal transduction pathways that result in exocytosis and transcription. The solution structure of one of these, the human FK506 and rapamycin binding protein (FKBP), has been determined by nuclear magnetic resonance (NMR). FKBP has a previously unobserved antiparallel beta-sheet folding topology that results in a novel loop crossing and produces a large cavity lined by a conserved array of aromatic residues; this cavity serves as the rotamase active site and drug-binding pocket. There are other significant structural features (such as a protruding positively charged loop and an apparently flexible loop) that may be involved in the biological activity of FKBP.
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{{ABSTRACT_PUBMED_1709301}}


==About this Structure==
==About this Structure==
1FKR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FKR OCA].  
1FKR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FKR OCA].  


==Reference==
==Reference==
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[[Category: Wandless, T J.]]
[[Category: Wandless, T J.]]
[[Category: Cis-trans isomerase]]
[[Category: Cis-trans isomerase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:26:41 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:24:58 2008''

Revision as of 00:25, 1 July 2008

File:1fkr.png

Template:STRUCTURE 1fkr

SOLUTION STRUCTURE OF FKBP, A ROTAMASE ENZYME AND RECEPTOR FOR FK506 AND RAPAMYCIN

Template:ABSTRACT PUBMED 1709301

About this Structure

1FKR is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of FKBP, a rotamase enzyme and receptor for FK506 and rapamycin., Michnick SW, Rosen MK, Wandless TJ, Karplus M, Schreiber SL, Science. 1991 May 10;252(5007):836-9. PMID:1709301

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