1fl2: Difference between revisions

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[[Image:1fl2.~~jpg~~|left|200px]]

[[Image:1fl2.png|left|200px]]

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~~'''~~CATALYTIC CORE COMPONENT OF THE ALKYLHYDROPEROXIDE REDUCTASE AHPF FROM E.COLI~~'''~~

===CATALYTIC CORE COMPONENT OF THE ALKYLHYDROPEROXIDE REDUCTASE AHPF FROM E.COLI===

~~==Overview==~~

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~~Alkylhydroperoxide reductases (AhpR~~, ~~EC 1.6.4.*) are essential for~~ the ~~oxygen tolerance of aerobic organisms by converting otherwise toxic hydroperoxides of lipids or nucleic acids~~ to the corresponding alcohols. The AhpF component belongs to the family of pyridine nucleotide-disulphide oxidoreductases and channels electrons from NAD(P)H towards the AhpC component which finally reduces cognate substrates. The structure of the catalytic core of the Escherichia coli AhpF (~~A212-A521) with a bound FAD cofactor was determined~~ at 1.~~9 A resolution in its oxidized state~~. ~~The dimeric arrangement of~~ the ~~AhpF catalytic core and the predicted interaction mode between the N~~-~~terminal PDO~~-~~like domain and the NADPH domain favours an intramolecular electron transfer between the two redox-active disulphide centres of AhpF.~~

The line below this paragraph, {{ABSTRACT_PUBMED_11243797}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 11243797 is the PubMed ID number.

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==About this Structure==

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[[Category: Fad]]

[[Category: Reactive oxygen]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ ~~2 16~~:27:13 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:25:35 2008''

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-[[Image:1fl2.jpg|left|200px]]
+{{Seed}}
+[[Image:1fl2.png|left|200px]]
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 {{STRUCTURE_1fl2|  PDB=1fl2  |  SCENE=  }}
-'''CATALYTIC CORE COMPONENT OF THE ALKYLHYDROPEROXIDE REDUCTASE AHPF FROM E.COLI'''
+===CATALYTIC CORE COMPONENT OF THE ALKYLHYDROPEROXIDE REDUCTASE AHPF FROM E.COLI===
-==Overview==
+<!--
-Alkylhydroperoxide reductases (AhpR, EC 1.6.4.*) are essential for the oxygen tolerance of aerobic organisms by converting otherwise toxic hydroperoxides of lipids or nucleic acids to the corresponding alcohols. The AhpF component belongs to the family of pyridine nucleotide-disulphide oxidoreductases and channels electrons from NAD(P)H towards the AhpC component which finally reduces cognate substrates. The structure of the catalytic core of the Escherichia coli AhpF (A212-A521) with a bound FAD cofactor was determined at 1.9 A resolution in its oxidized state. The dimeric arrangement of the AhpF catalytic core and the predicted interaction mode between the N-terminal PDO-like domain and the NADPH domain favours an intramolecular electron transfer between the two redox-active disulphide centres of AhpF.
+The line below this paragraph, {{ABSTRACT_PUBMED_11243797}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 11243797 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_11243797}}
 ==About this Structure==
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 [[Category: Fad]]
 [[Category: Reactive oxygen]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 16:27:13 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 03:25:35 2008''