Glucocorticoids: Difference between revisions

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*[[Glucocorticoid receptor]]

*[[Forkhead box proteins]] (FOX) are transcription factors involved in regulation of gene expression.<ref>PMID:17889656</ref>. '''FOXO1''' activation contributes to '''glucocorticoid'''-induced beta cell death<ref>PMID:23435785</ref>.

*[[Forkhead box proteins]] (FOX) are transcription factors involved in regulation of gene expression.<ref>PMID:17889656</ref>. '''FOXO1''' activation contributes to '''glucocorticoid'''-induced beta cell death<ref>PMID:23435785</ref>. FOX contain a DNA-binding motif (DBD) of 80-100 amino acids having a winged-helix shape.

**<scene name='47/479231/Cv/5'>Human FoxO1 DNA-binding domain with DNA, Ca+2 and Cl- ions</scene>.

**<scene name='47/479231/Cv/6'>Ca coordination site</scene>. Water molecules shown as red spheres.

**<scene name='47/479231/Cv/7'>Cl coordination site</scene>.

*[[Nuclear receptor coactivator]] (NCOA) is a protein recruited by nuclear receptors in order to enhance or repress DNA transcription. NCOA is involved in coactivation with transcription factors<ref>PMID:9121485</ref>. '''NCOA1''' shows histone acetyltransferase activity and is required for '''steroid hormone''' response. '''NCOA2''' is a DNA transcription coactivator with '''glucocorticoid''' receptor.

*[[Thioredoxin Reductase]] (TrxR) is an enzyme which reduces thioredoxin using NADPH<ref>PMID:11012661</ref>. Mutations in TrxR-2 are associated with familial '''glucocorticoid''' deficiency<ref>PMID:24601690</ref>.

**<scene name='49/494427/Cv/7'>NCOA/STAT6 transactivator domain LXXLL peptide interactions</scene>.

*Microsomal [[Prostaglandin E synthase]] (PGES) converts cyclooxygenase (COX)-derived prostaglandin to PGE2. It is membrane-associated and belongs to the microsomal glutathione S-transferase family. PGES is preferentially linked with the inducible COX-2<ref>PMID:12432931</ref> . PGES is induced by proinflammatory stimuli and down-regulated by anti-inflammatory '''glucocorticoids'''<ref>PMID:16336776</ref>.

**<scene name='49/494427/Cv/8'>1st Iod coordination site</scene>.

**<scene name='49/494427/Cv/9'>2nd Iod coordination site</scene>. Water molecules are shown as red spheres.

**<scene name='49/494427/Cv/10'>3th and 4th Iod coordination sites</scene>.

**<scene name='49/494427/Cv/11'>5th Iod coordination site</scene>.

*[[Thioredoxin Reductase]] (TrxR) is an enzyme which reduces thioredoxin using NADPH<ref>PMID:11012661</ref>. Mutations in TrxR-2 are associated with familial '''glucocorticoid''' deficiency<ref>PMID:24601690</ref>. Thioredoxin Reductase (TrxR) is an enzyme which reduces thioredoxin using NADPH<ref>PMID:11012661</ref>. '''TrxR-2''' is mitochondrial. For more details see [[User:Sarah Abdalla/Thioredoxin Reductase]]. TrxR and Trx form an <scene name='43/433123/Cv/6'>intramolecular Cys-Cys bond</scene><ref>PMID:21750537</ref>. <scene name='43/433123/Cv/7'>FAD binding site</scene>. Water molecules are shown as red spheres.

*Microsomal [[Prostaglandin E synthase]] (PGES) converts cyclooxygenase (COX)-derived prostaglandin to PGE2. It is membrane-associated and belongs to the microsomal glutathione S-transferase family. PGES is preferentially linked with the inducible COX-2<ref>PMID:12432931</ref> . PGES is induced by proinflammatory stimuli and down-regulated by anti-inflammatory '''glucocorticoids'''<ref>PMID:16336776</ref>. Microsomal ''Prostaglandin E synthase'' <scene name='77/778890/Cv/2'>is membrane-associated</scene> (coordinates are from [http://opm.phar.umich.edu/protein.php?extrapdb=4yl0 OPM database]. The <scene name='77/778890/Cv/6'>anti-inflammatory inhibitor binds to PGES in a pocket above the glutathione and interacts with various side-chains of a helix</scene><ref>PMID:25961169</ref>. Water molecules are shown as red spheres.

</StructureSection>

== References ==

Glucocorticoids: Difference between revisions

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 <StructureSection load='3g6r' size='350' side='right' caption='Rat glucocorticoid receptor DNA-binding domain dimer complex with DNA and Zn+2 ions (grey) (PDB entry [[3g6r]])' scene=''>
 *[[Glucocorticoid receptor]]
-*[[Forkhead box proteins]] (FOX) are transcription factors involved in regulation of gene expression.<ref>PMID:17889656</ref>. '''FOXO1''' activation contributes to '''glucocorticoid'''-induced beta cell death<ref>PMID:23435785</ref>.
+*[[Forkhead box proteins]] (FOX) are transcription factors involved in regulation of gene expression.<ref>PMID:17889656</ref>. '''FOXO1''' activation contributes to '''glucocorticoid'''-induced beta cell death<ref>PMID:23435785</ref>. FOX contain a DNA-binding motif (DBD) of 80-100 amino acids having a winged-helix shape.
+**<scene name='47/479231/Cv/5'>Human FoxO1 DNA-binding domain with DNA, Ca+2 and Cl- ions</scene>.
+**<scene name='47/479231/Cv/6'>Ca coordination site</scene>. Water molecules shown as red spheres.
+**<scene name='47/479231/Cv/7'>Cl coordination site</scene>.
 *[[Nuclear receptor coactivator]] (NCOA) is a protein recruited by nuclear receptors in order to enhance or repress DNA transcription. NCOA is involved in coactivation with transcription factors<ref>PMID:9121485</ref>. '''NCOA1''' shows histone acetyltransferase activity and is required for '''steroid hormone''' response. '''NCOA2''' is a DNA transcription coactivator with '''glucocorticoid''' receptor.
-*[[Thioredoxin Reductase]] (TrxR) is an enzyme which reduces thioredoxin using NADPH<ref>PMID:11012661</ref>. Mutations in TrxR-2 are associated with familial '''glucocorticoid''' deficiency<ref>PMID:24601690</ref>.
+**<scene name='49/494427/Cv/7'>NCOA/STAT6 transactivator domain LXXLL peptide interactions</scene>.
-*Microsomal [[Prostaglandin E synthase]] (PGES) converts cyclooxygenase (COX)-derived prostaglandin to PGE2. It is membrane-associated and belongs to the microsomal glutathione S-transferase family. PGES is preferentially linked with the inducible COX-2<ref>PMID:12432931</ref> . PGES is induced by proinflammatory stimuli and down-regulated by anti-inflammatory '''glucocorticoids'''<ref>PMID:16336776</ref>.
+**<scene name='49/494427/Cv/8'>1st Iod coordination site</scene>.
+**<scene name='49/494427/Cv/9'>2nd Iod coordination site</scene>. Water molecules are shown as red spheres.
+**<scene name='49/494427/Cv/10'>3th and 4th Iod coordination sites</scene>.
+**<scene name='49/494427/Cv/11'>5th Iod coordination site</scene>.
+*[[Thioredoxin Reductase]] (TrxR) is an enzyme which reduces thioredoxin using NADPH<ref>PMID:11012661</ref>. Mutations in TrxR-2 are associated with familial '''glucocorticoid''' deficiency<ref>PMID:24601690</ref>. Thioredoxin Reductase (TrxR) is an enzyme which reduces thioredoxin using NADPH<ref>PMID:11012661</ref>.  '''TrxR-2''' is mitochondrial. For more details see [[User:Sarah Abdalla/Thioredoxin Reductase]]. TrxR and Trx form an <scene name='43/433123/Cv/6'>intramolecular Cys-Cys bond</scene><ref>PMID:21750537</ref>. <scene name='43/433123/Cv/7'>FAD binding site</scene>. Water molecules are shown as red spheres.
+*Microsomal [[Prostaglandin E synthase]] (PGES) converts cyclooxygenase (COX)-derived prostaglandin to PGE2. It is membrane-associated and belongs to the microsomal glutathione S-transferase family. PGES is preferentially linked with the inducible COX-2<ref>PMID:12432931</ref> . PGES is induced by proinflammatory stimuli and down-regulated by anti-inflammatory '''glucocorticoids'''<ref>PMID:16336776</ref>. Microsomal ''Prostaglandin E synthase'' <scene name='77/778890/Cv/2'>is membrane-associated</scene> (coordinates are from [http://opm.phar.umich.edu/protein.php?extrapdb=4yl0 OPM database]. The <scene name='77/778890/Cv/6'>anti-inflammatory inhibitor binds to PGES in a pocket above the glutathione and interacts with various side-chains of a helix</scene><ref>PMID:25961169</ref>. Water molecules are shown as red spheres.
 </StructureSection>
 == References ==
 <references/>