1fli: Difference between revisions

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[[Image:1fli.~~gif~~|left|200px]]

[[Image:1fli.png|left|200px]]

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~~'''~~DNA-BINDING DOMAIN OF FLI-1~~'''~~

===DNA-BINDING DOMAIN OF FLI-1===

~~==Overview==~~

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~~Members of the ets family of transcription factors share a conserved DNA-binding domain~~, ~~the ets domain. By using multidimensional NMR~~, ~~we have determined~~ the ~~structure of~~ the ~~ets domain of human Fli-1 in the DNA-bound form~~. ~~It consists of three alpha-helices and a four-stranded beta-sheet~~, ~~similar to structures of~~ the ~~class of helix-turn-helix DNA binding proteins first found in the catabolite activator protein of Escherichia coli~~. ~~NMR and mutagenesis experiments suggest that in comparison to structurally related proteins, the ets domain uses a new variation of the helix~~-~~turn~~-~~helix motif for binding to DNA.~~

The line below this paragraph, {{ABSTRACT_PUBMED_7773776}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 7773776 is the PubMed ID number.

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==About this Structure==

1FLI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FLI OCA].

1FLI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FLI OCA].

==Reference==

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[[Category: Yu, L.]]

[[Category: Transcription/dna]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ ~~2 16~~:28:02 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:26:34 2008''

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-[[Image:1fli.gif|left|200px]]
+{{Seed}}
+[[Image:1fli.png|left|200px]]
 <!--
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 {{STRUCTURE_1fli|  PDB=1fli  |  SCENE=  }}
-'''DNA-BINDING DOMAIN OF FLI-1'''
+===DNA-BINDING DOMAIN OF FLI-1===
-==Overview==
+<!--
-Members of the ets family of transcription factors share a conserved DNA-binding domain, the ets domain. By using multidimensional NMR, we have determined the structure of the ets domain of human Fli-1 in the DNA-bound form. It consists of three alpha-helices and a four-stranded beta-sheet, similar to structures of the class of helix-turn-helix DNA binding proteins first found in the catabolite activator protein of Escherichia coli. NMR and mutagenesis experiments suggest that in comparison to structurally related proteins, the ets domain uses a new variation of the helix-turn-helix motif for binding to DNA.
+The line below this paragraph, {{ABSTRACT_PUBMED_7773776}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 7773776 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_7773776}}
 ==About this Structure==
-FLI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FLI OCA].
+FLI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FLI OCA].
 ==Reference==
@@ Line 31: / Line 35: @@
 [[Category: Yu, L.]]
 [[Category: Transcription/dna]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 16:28:02 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 03:26:34 2008''