7n03: Difference between revisions

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==Crystal structure of MTH1 in complex with compound 31==

== Structural highlights ==

<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7N03 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=7N03 FirstGlance].

<table><tr><td colspan='2'>[[7n03]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7N03 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=7N03 FirstGlance].

</td></tr><tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=7n03 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7n03 OCA], [https://pdbe.org/7n03 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7n03 RCSB], [https://www.ebi.ac.uk/pdbsum/7n03 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7n03 ProSAT]</td></tr>

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZRP:4-anilino-6-(hexylamino)-N-methylquinoline-3-carboxamide'>ZRP</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=7n03 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7n03 OCA], [https://pdbe.org/7n03 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7n03 RCSB], [https://www.ebi.ac.uk/pdbsum/7n03 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7n03 ProSAT]</td></tr>

</table>

== Function ==

[[https://www.uniprot.org/uniprot/8ODP_HUMAN 8ODP_HUMAN]] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.<ref>PMID:10373420</ref> <ref>PMID:10608900</ref> <ref>PMID:11139615</ref> <ref>PMID:12857738</ref> <ref>PMID:22556419</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Eron SJ]]

[[Category: Eron, S J]]

[[Category: Hydrolase]]

[[Category: Hydrolase-hydrolase inhibitor complex]]

[[Category: Inhibitor]]

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 ==Crystal structure of MTH1 in complex with compound 31==
-<StructureSection load='7n03' size='340' side='right'caption='[[7n03]]' scene=''>
+<StructureSection load='7n03' size='340' side='right'caption='[[7n03]], [[Resolution|resolution]] 1.13&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7N03 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7N03 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[7n03]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7N03 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7N03 FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7n03 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7n03 OCA], [https://pdbe.org/7n03 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7n03 RCSB], [https://www.ebi.ac.uk/pdbsum/7n03 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7n03 ProSAT]</span></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZRP:4-anilino-6-(hexylamino)-N-methylquinoline-3-carboxamide'>ZRP</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7n03 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7n03 OCA], [https://pdbe.org/7n03 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7n03 RCSB], [https://www.ebi.ac.uk/pdbsum/7n03 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7n03 ProSAT]</span></td></tr>
 </table>
+== Function ==
+[[https://www.uniprot.org/uniprot/8ODP_HUMAN 8ODP_HUMAN]] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.<ref>PMID:10373420</ref> <ref>PMID:10608900</ref> <ref>PMID:11139615</ref> <ref>PMID:12857738</ref> <ref>PMID:22556419</ref>
+== References ==
+<references/>
 __TOC__
 </StructureSection>
 [[Category: Large Structures]]
-[[Category: Eron SJ]]
+[[Category: Eron, S J]]
+[[Category: Hydrolase]]
+[[Category: Hydrolase-hydrolase inhibitor complex]]
+[[Category: Inhibitor]]