1xsw: Difference between revisions
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==The solid-state NMR structure of Kaliotoxin== | ==The solid-state NMR structure of Kaliotoxin== | ||
<StructureSection load='1xsw' size='340' side='right'caption='[[1xsw | <StructureSection load='1xsw' size='340' side='right'caption='[[1xsw]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1xsw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[1xsw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Androctonus_mauritanicus_mauritanicus Androctonus mauritanicus mauritanicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XSW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XSW FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solid-state NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xsw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xsw OCA], [https://pdbe.org/1xsw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xsw RCSB], [https://www.ebi.ac.uk/pdbsum/1xsw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xsw ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xsw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xsw OCA], [https://pdbe.org/1xsw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xsw RCSB], [https://www.ebi.ac.uk/pdbsum/1xsw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xsw ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/KAX31_ANDMA KAX31_ANDMA] Potent inhibitor of large conductance calcium-activated potassium channels (BK-Ca). Also binds to the dendrotoxin sensitive voltage-dependent potassium channel. It appears to block channel activity by a simple bimolecular inhibition process. Induces a transient period of fast flickering in the channel openings, followed by an almost complete blockade of the channel. Its binding affinity to rat brain synaptosomes is 5-fold higher than this of KTX-3. Binding of the toxin to the channel is associated with significant structural rearrangements in both molecules. | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Androctonus mauritanicus mauritanicus]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Baldus | [[Category: Baldus M]] | ||
[[Category: Becker | [[Category: Becker S]] | ||
[[Category: Giller | [[Category: Giller K]] | ||
[[Category: Lange | [[Category: Lange A]] | ||
[[Category: Pongs | [[Category: Pongs O]] | ||
[[Category: Seidel | [[Category: Seidel K]] | ||
Revision as of 07:57, 15 May 2024
The solid-state NMR structure of Kaliotoxin
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