1yj5: Difference between revisions

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<StructureSection load='1yj5' size='340' side='right'caption='[[1yj5]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<StructureSection load='1yj5' size='340' side='right'caption='[[1yj5]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1yj5]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YJ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YJ5 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1yj5]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YJ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YJ5 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Polynucleotide_5'-hydroxyl-kinase Polynucleotide 5'-hydroxyl-kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.78 2.7.1.78] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yj5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yj5 OCA], [https://pdbe.org/1yj5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yj5 RCSB], [https://www.ebi.ac.uk/pdbsum/1yj5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yj5 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yj5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yj5 OCA], [https://pdbe.org/1yj5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yj5 RCSB], [https://www.ebi.ac.uk/pdbsum/1yj5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yj5 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/PNKP_MOUSE PNKP_MOUSE]] Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone.  
[https://www.uniprot.org/uniprot/PNKP_MOUSE PNKP_MOUSE] Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Polynucleotide 5'-hydroxyl-kinase]]
[[Category: Bernstein NK]]
[[Category: Bernstein, N K]]
[[Category: Cass CE]]
[[Category: Cass, C E]]
[[Category: Cui D]]
[[Category: Cui, D]]
[[Category: Durocher D]]
[[Category: Durocher, D]]
[[Category: Galicia S]]
[[Category: Galicia, S]]
[[Category: Glover JNM]]
[[Category: Glover, J N.M]]
[[Category: Green R]]
[[Category: Green, R]]
[[Category: Karimi-Busheri F]]
[[Category: Karimi-Busheri, F]]
[[Category: Koch CA]]
[[Category: Koch, C A]]
[[Category: Mani RS]]
[[Category: Mani, R S]]
[[Category: Rakovszky ML]]
[[Category: Rakovszky, M L]]
[[Category: Weinfeld M]]
[[Category: Weinfeld, M]]
[[Category: Williams RS]]
[[Category: Williams, R S]]
[[Category: Beta sandwich]]
[[Category: P-loop]]
[[Category: Transferase]]
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