1fms: Difference between revisions

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[[Image:1fms.gif|left|200px]]
{{Seed}}
[[Image:1fms.png|left|200px]]


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{{STRUCTURE_1fms|  PDB=1fms  |  SCENE=  }}  
{{STRUCTURE_1fms|  PDB=1fms  |  SCENE=  }}  


'''Structure of complex between cyclohexyl-bis-furamidine and d(CGCGAATTCGCG)'''
===Structure of complex between cyclohexyl-bis-furamidine and d(CGCGAATTCGCG)===




==Overview==
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2,5-Bis-[4-(N-cyclobutyl-amidino)phenyl] furan and 2,5-bis-[4-(N-cyclohexyl-amidino)phenyl] furan have activity against Pneumocystis carinii and also show cytotoxicity against several tumour cell lines. These activities are correlated with DNA-binding abilities; the crystal structures of complexes with the DNA sequence d(CGCGAATTCGCG) is reported here. Interactions with, and effects on, the DNA minor groove, are found to be factors in the biological properties of these compounds.
The line below this paragraph, {{ABSTRACT_PUBMED_11128631}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 11128631 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11128631}}


==About this Structure==
==About this Structure==
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[[Category: Simpson, I J.]]
[[Category: Simpson, I J.]]
[[Category: Dna-drug minor groove complex]]
[[Category: Dna-drug minor groove complex]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:30:53 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:31:24 2008''
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