1ck7: Difference between revisions

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[[Image:1ck7.gif|left|200px]]<br />

[[Image:1ck7.gif|left|200px]]<br /><applet load="1ck7" size="350" color="white" frame="true" align="right" spinBox="true"

<applet load="1ck7" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

caption="1ck7, resolution 2.8Å" />

'''GELATINASE A (FULL-LENGTH)'''<br />

==Overview==

Matrix metalloproteinases (MMPs) catalyze extracellular matrix, degradation. Control of their activity is a promising target for therapy, of diseases characterized by abnormal connective tissue turnover. MMPs are, expressed as latent proenzymes that are activated by proteolytic cleavage, that triggers a conformational change in the propeptide (cysteine switch)., The structure of proMMP-2 reveals how the propeptide shields the catalytic, cleft and that the cysteine switch may operate through cleavage of loops, essential for propeptide stability.

Matrix metalloproteinases (MMPs) catalyze extracellular matrix degradation. Control of their activity is a promising target for therapy of diseases characterized by abnormal connective tissue turnover. MMPs are expressed as latent proenzymes that are activated by proteolytic cleavage that triggers a conformational change in the propeptide (cysteine switch). The structure of proMMP-2 reveals how the propeptide shields the catalytic cleft and that the cysteine switch may operate through cleavage of loops essential for propeptide stability.

==Disease==

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==About this Structure==

1CK7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN, CA, CL, NA and SO4 as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Gelatinase_A Gelatinase A], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.24 3.4.24.24] Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1CK7 OCA].

1CK7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=CL:'>CL</scene>, <scene name='pdbligand=NA:'>NA</scene> and <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Gelatinase_A Gelatinase A], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.24 3.4.24.24] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CK7 OCA].

==Reference==

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[[Category: metalloproteinase]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Mon Nov~~ 12 16:22:~~36 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:06:55 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1ck7.gif|left|200px]]<br />
+[[Image:1ck7.gif|left|200px]]<br /><applet load="1ck7" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="1ck7" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="1ck7, resolution 2.8&Aring;" />
 '''GELATINASE A (FULL-LENGTH)'''<br />
 ==Overview==
-Matrix metalloproteinases (MMPs) catalyze extracellular matrix, degradation. Control of their activity is a promising target for therapy, of diseases characterized by abnormal connective tissue turnover. MMPs are, expressed as latent proenzymes that are activated by proteolytic cleavage, that triggers a conformational change in the propeptide (cysteine switch)., The structure of proMMP-2 reveals how the propeptide shields the catalytic, cleft and that the cysteine switch may operate through cleavage of loops, essential for propeptide stability.
+Matrix metalloproteinases (MMPs) catalyze extracellular matrix degradation. Control of their activity is a promising target for therapy of diseases characterized by abnormal connective tissue turnover. MMPs are expressed as latent proenzymes that are activated by proteolytic cleavage that triggers a conformational change in the propeptide (cysteine switch). The structure of proMMP-2 reveals how the propeptide shields the catalytic cleft and that the cysteine switch may operate through cleavage of loops essential for propeptide stability.
 ==Disease==
@@ Line 11: / Line 10: @@
 ==About this Structure==
-CK7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN, CA, CL, NA and SO4 as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Gelatinase_A Gelatinase A], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.24 3.4.24.24] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1CK7 OCA].
+CK7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=CL:'>CL</scene>, <scene name='pdbligand=NA:'>NA</scene> and <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Gelatinase_A Gelatinase A], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.24 3.4.24.24] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CK7 OCA].
 ==Reference==
@@ Line 35: / Line 34: @@
 [[Category: metalloproteinase]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 16:22:36 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:06:55 2008''