1fng: Difference between revisions

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[[Image:1fng.gif|left|200px]]
{{Seed}}
[[Image:1fng.png|left|200px]]


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{{STRUCTURE_1fng|  PDB=1fng  |  SCENE=  }}  
{{STRUCTURE_1fng|  PDB=1fng  |  SCENE=  }}  


'''HISTOCOMPATIBILITY ANTIGEN'''
===HISTOCOMPATIBILITY ANTIGEN===




==Overview==
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To better understand TCR discrimination of multiple ligands, we have analyzed the crystal structures of two Hb peptide/I-E(k) complexes that differ by only a single amino acid substitution at the P6 anchor position within the peptide (E73D). Detailed comparison of multiple independently determined structures at 1.9 A resolution reveals that removal of a single buried methylene group can alter a critical portion of the TCR recognition surface. Significant variance was observed in the peptide P5-P8 main chain as well as a rotamer difference at LeuP8, approximately 10 A distal from the substitution. No significant variations were observed in the conformation of the two MHC class II molecules. The ligand alteration results in two peptide/MHC complexes that generate bulk T cell responses that are distinct and essentially nonoverlapping. For the Hb-specific T cell 3.L2, substitution reduces the potency of the ligand 1000-fold. Soluble 3.L2 TCR binds the two peptide/MHC complexes with similar affinity, although with faster kinetics. These results highlight the role of subtle variations in MHC Ag presentation on T cell activation and signaling.
The line below this paragraph, {{ABSTRACT_PUBMED_11207290}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 11207290 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11207290}}


==About this Structure==
==About this Structure==
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[[Category: Mhc]]
[[Category: Mhc]]
[[Category: Peptide]]
[[Category: Peptide]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:32:12 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:36:58 2008''

Revision as of 00:36, 1 July 2008

File:1fng.png

Template:STRUCTURE 1fng

HISTOCOMPATIBILITY ANTIGEN

Template:ABSTRACT PUBMED 11207290

About this Structure

1FNG is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural and functional consequences of altering a peptide MHC anchor residue., Kersh GJ, Miley MJ, Nelson CA, Grakoui A, Horvath S, Donermeyer DL, Kappler J, Allen PM, Fremont DH, J Immunol. 2001 Mar 1;166(5):3345-54. PMID:11207290

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