1fnl: Difference between revisions

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[[Image:1fnl.gif|left|200px]]
{{Seed}}
[[Image:1fnl.png|left|200px]]


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{{STRUCTURE_1fnl|  PDB=1fnl  |  SCENE=  }}  
{{STRUCTURE_1fnl|  PDB=1fnl  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF A HUMAN FCGRIII'''
===CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF A HUMAN FCGRIII===




==Overview==
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Fc receptors play a major role in immune defenses against pathogens and in inflammatory processes. The crystal structure of a human immunoglobulin receptor, FcgammaRIIIb, has been determined to 1.8 A resolution. The overall fold consists of two immunoglobulin-like domains with an acute interdomain hinge angle of approximately 50 degrees. Trp-113, wedged between the N-terminal D1 and the C-terminal D2 domains, appears to further restrict the hinge angle. The putative Fc binding region of the receptor carries a net positive charge complementary to the negative-charged receptor binding regions on Fc. A 1:1 binding stoichiometry between the receptor and Fc was measured by both the equilibrium and nonequilibrium size-exclusion chromatography. Two separate parallel dimers are observed in the crystal lattice, offering intriguing models for receptor aggregation.
The line below this paragraph, {{ABSTRACT_PUBMED_11021536}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 11021536 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11021536}}


==About this Structure==
==About this Structure==
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[[Category: Immunoglobulin-like]]
[[Category: Immunoglobulin-like]]
[[Category: Receptor]]
[[Category: Receptor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:32:26 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:37:39 2008''

Revision as of 00:37, 1 July 2008

File:1fnl.png

Template:STRUCTURE 1fnl

CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF A HUMAN FCGRIII

Template:ABSTRACT PUBMED 11021536

About this Structure

1FNL is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the extracellular domain of a human Fc gamma RIII., Zhang Y, Boesen CC, Radaev S, Brooks AG, Fridman WH, Sautes-Fridman C, Sun PD, Immunity. 2000 Sep;13(3):387-95. PMID:11021536

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