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==Solution structure of Dermaseptin antimicrobial peptide truncated, mutated analog, K4-S4(1-13)a==
==Solution structure of Dermaseptin antimicrobial peptide truncated, mutated analog, K4-S4(1-13)a==
<StructureSection load='2dd6' size='340' side='right'caption='[[2dd6]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
<StructureSection load='2dd6' size='340' side='right'caption='[[2dd6]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2dd6]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DD6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DD6 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2dd6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Phyllomedusa_sauvagii Phyllomedusa sauvagii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DD6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DD6 FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2dcx|2dcx]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dd6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dd6 OCA], [https://pdbe.org/2dd6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dd6 RCSB], [https://www.ebi.ac.uk/pdbsum/2dd6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dd6 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dd6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dd6 OCA], [https://pdbe.org/2dd6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dd6 RCSB], [https://www.ebi.ac.uk/pdbsum/2dd6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dd6 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/DMS4_PHYSA DMS4_PHYSA]] Possesses a potent antimicrobial activity against Gram-negative and Gram-positive bacteria, fungi, protozoa, and the enveloped herpes simplex virus type 1. Probably acts by disturbing membrane functions with its amphipathic structure. Binds to healthy erythrocytes (this binding is receptor independent), and has strong hemolytic activity. Does not bind to P.falciparum infected erythrocytes, but accumulates within the parasite. Kills the parasite, and only at high concentrations has a hemolytic activity on the host cell.<ref>PMID:8306981</ref> <ref>PMID:9395500</ref>
[https://www.uniprot.org/uniprot/DRS4_PHYSA DRS4_PHYSA] Potent antimicrobial peptide with activity against bacteria and protozoa (By similarity). Also has activity against fungi (PubMed:8306981). Also shows activity against enveloped herpes simplex virus type 1 (PubMed:11782932). Probably acts by disturbing membrane functions with its amphipathic structure (Probable). Binds to healthy erythrocytes (this binding is receptor independent), and has strong hemolytic activity (PubMed:9395500). Does not bind to P.falciparum infected erythrocytes, but accumulates within the parasite (PubMed:9395500). Kills the parasite, and only at high concentrations has a hemolytic activity on the host cell (PubMed:9395500). In vitro, shows high spermicidal activities (PubMed:16307969).[UniProtKB:P24302]<ref>PMID:11782932</ref> <ref>PMID:16307969</ref> <ref>PMID:8306981</ref> <ref>PMID:9395500</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Fish, A]]
[[Category: Phyllomedusa sauvagii]]
[[Category: Mor, A]]
[[Category: Fish A]]
[[Category: Rotem, S]]
[[Category: Mor A]]
[[Category: Shalev, D E]]
[[Category: Rotem S]]
[[Category: Alpha helix]]
[[Category: Shalev DE]]
[[Category: Antimicrobial protein]]
Retrieved from "https://proteopedia.org/2dd6"