1fo0: Difference between revisions

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[[Image:1fo0.gif|left|200px]]
{{Seed}}
[[Image:1fo0.png|left|200px]]


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{{STRUCTURE_1fo0|  PDB=1fo0  |  SCENE=  }}  
{{STRUCTURE_1fo0|  PDB=1fo0  |  SCENE=  }}  


'''MURINE ALLOREACTIVE SCFV TCR-PEPTIDE-MHC CLASS I MOLECULE COMPLEX'''
===MURINE ALLOREACTIVE SCFV TCR-PEPTIDE-MHC CLASS I MOLECULE COMPLEX===




==Overview==
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Many T cell receptors (TCRs) that are selected to respond to foreign peptide antigens bound to self major histocompatibility complex (MHC) molecules are also reactive with allelic variants of self-MHC molecules. This property, termed alloreactivity, causes graft rejection and graft-versus-host disease. The structural features of alloreactivity have yet to be defined. We now present a basis for this cross-reactivity, elucidated by the crystal structure of a complex involving the BM3.3 TCR and a naturally processed octapeptide bound to the H-2Kb allogeneic MHC class I molecule. A distinguishing feature of this complex is that the eleven-residue-long complementarity-determining region 3 (CDR3) found in the BM3.3 TCR alpha chain folds away from the peptide binding groove and makes no contact with the bound peptide, the latter being exclusively contacted by the BM3.3 CDR3 beta. Our results formally establish that peptide-specific, alloreactive TCRs interact with allo-MHC in a register similar to the one they use to contact self-MHC molecules.
The line below this paragraph, {{ABSTRACT_PUBMED_11017099}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 11017099 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11017099}}


==About this Structure==
==About this Structure==
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[[Category: T cell receptor]]
[[Category: T cell receptor]]
[[Category: Tcr-pmhc complex]]
[[Category: Tcr-pmhc complex]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:33:24 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:39:14 2008''

Revision as of 00:39, 1 July 2008

File:1fo0.png

Template:STRUCTURE 1fo0

MURINE ALLOREACTIVE SCFV TCR-PEPTIDE-MHC CLASS I MOLECULE COMPLEX

Template:ABSTRACT PUBMED 11017099

About this Structure

1FO0 is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of a T cell receptor bound to an allogeneic MHC molecule., Reiser JB, Darnault C, Guimezanes A, Gregoire C, Mosser T, Schmitt-Verhulst AM, Fontecilla-Camps JC, Malissen B, Housset D, Mazza G, Nat Immunol. 2000 Oct;1(4):291-7. PMID:11017099

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