1cmi: Difference between revisions
New page: left|200px<br /> <applet load="1cmi" size="450" color="white" frame="true" align="right" spinBox="true" caption="1cmi, resolution 2.5Å" /> '''STRUCTURE OF THE HUM... |
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[[Image:1cmi.gif|left|200px]]<br /> | [[Image:1cmi.gif|left|200px]]<br /><applet load="1cmi" size="350" color="white" frame="true" align="right" spinBox="true" | ||
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caption="1cmi, resolution 2.5Å" /> | caption="1cmi, resolution 2.5Å" /> | ||
'''STRUCTURE OF THE HUMAN PIN/LC8 DIMER WITH A BOUND PEPTIDE'''<br /> | '''STRUCTURE OF THE HUMAN PIN/LC8 DIMER WITH A BOUND PEPTIDE'''<br /> | ||
==Overview== | ==Overview== | ||
The structure of the protein known both as neuronal nitric oxide synthase | The structure of the protein known both as neuronal nitric oxide synthase inhibitory protein, PIN (protein inhibitor of nNOS), and also as the 8 kDa dynein light chain (LC8) has been solved by X-ray diffraction. Two PIN/LC8 monomers related by a two-fold axis form a rectangular dimer. Two pairs of alpha-helices cover opposite faces, and each pair of helices packs against a beta-sheet with five antiparallel beta-strands. Each five-stranded beta-sheet contains four strands from one monomer and a fifth strand from the other monomer. A 13-residue peptide from nNOS is bound to the dimer in a deep hydrophobic groove as a sixth antiparallel beta-strand. The structure provides key insights into dimerization of and peptide binding by the multifunctional PIN/LC8 protein. | ||
==Disease== | ==Disease== | ||
Known diseases associated with this structure: Colorectal cancer, somatic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=604258 604258]], Esophageal cancer OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=604050 604050 | Known diseases associated with this structure: Colorectal cancer, somatic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=604258 604258]], Esophageal cancer OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=604050 604050]], Lung cancer OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=604050 604050]] | ||
==About this Structure== | ==About this Structure== | ||
1CMI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure | 1CMI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry 1B1W. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CMI OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: pin]] | [[Category: pin]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:07:33 2008'' | ||
Revision as of 10:07, 21 February 2008
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STRUCTURE OF THE HUMAN PIN/LC8 DIMER WITH A BOUND PEPTIDE
Overview
The structure of the protein known both as neuronal nitric oxide synthase inhibitory protein, PIN (protein inhibitor of nNOS), and also as the 8 kDa dynein light chain (LC8) has been solved by X-ray diffraction. Two PIN/LC8 monomers related by a two-fold axis form a rectangular dimer. Two pairs of alpha-helices cover opposite faces, and each pair of helices packs against a beta-sheet with five antiparallel beta-strands. Each five-stranded beta-sheet contains four strands from one monomer and a fifth strand from the other monomer. A 13-residue peptide from nNOS is bound to the dimer in a deep hydrophobic groove as a sixth antiparallel beta-strand. The structure provides key insights into dimerization of and peptide binding by the multifunctional PIN/LC8 protein.
Disease
Known diseases associated with this structure: Colorectal cancer, somatic OMIM:[604258], Esophageal cancer OMIM:[604050], Lung cancer OMIM:[604050]
About this Structure
1CMI is a Single protein structure of sequence from Homo sapiens. This structure supersedes the now removed PDB entry 1B1W. Full crystallographic information is available from OCA.
Reference
Structure of the PIN/LC8 dimer with a bound peptide., Liang J, Jaffrey SR, Guo W, Snyder SH, Clardy J, Nat Struct Biol. 1999 Aug;6(8):735-40. PMID:10426949
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