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==Solution Structure of the RGS domain from human RGS18==
==Solution Structure of the RGS domain from human RGS18==
<StructureSection load='2jm5' size='340' side='right'caption='[[2jm5]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2jm5' size='340' side='right'caption='[[2jm5]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2jm5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JM5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JM5 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2jm5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JM5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JM5 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2owi|2owi]]</div></td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jm5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jm5 OCA], [https://pdbe.org/2jm5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jm5 RCSB], [https://www.ebi.ac.uk/pdbsum/2jm5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jm5 ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RGS18, RGS13 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jm5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jm5 OCA], [https://pdbe.org/2jm5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jm5 RCSB], [https://www.ebi.ac.uk/pdbsum/2jm5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jm5 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/RGS18_HUMAN RGS18_HUMAN]] Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha-2, G(i) alpha-3 and G(q) alpha.<ref>PMID:11042171</ref> <ref>PMID:11955952</ref>
[https://www.uniprot.org/uniprot/RGS18_HUMAN RGS18_HUMAN] Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha-2, G(i) alpha-3 and G(q) alpha.<ref>PMID:11042171</ref> <ref>PMID:11955952</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C]]
[[Category: Arrowsmith C]]
[[Category: Ball, L J]]
[[Category: Ball LJ]]
[[Category: Bray, J]]
[[Category: Bray J]]
[[Category: Brockmann, C]]
[[Category: Brockmann C]]
[[Category: Diehl, A]]
[[Category: Diehl A]]
[[Category: Doyle, D A]]
[[Category: Doyle DA]]
[[Category: Edwards, A]]
[[Category: Edwards A]]
[[Category: Elkins, J]]
[[Category: Elkins J]]
[[Category: Gileadi, C]]
[[Category: Gileadi C]]
[[Category: Higman, V A]]
[[Category: Higman VA]]
[[Category: Leidert, M]]
[[Category: Leidert M]]
[[Category: Oschkinat, H]]
[[Category: Oschkinat H]]
[[Category: Phillips, C]]
[[Category: Phillips C]]
[[Category: Structural genomic]]
[[Category: Schmieder P]]
[[Category: Schmieder, P]]
[[Category: Schoch G]]
[[Category: Schoch, G]]
[[Category: Soundararajan M]]
[[Category: Soundararajan, M]]
[[Category: Sundstrom M]]
[[Category: Sundstrom, M]]
[[Category: Weigelt J]]
[[Category: Weigelt, J]]
[[Category: Yang X]]
[[Category: Yang, X]]
[[Category: Sgc]]
[[Category: Signaling protein]]
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