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==Solution structure of the leader sequence of the patellamide precursor peptide, PatE1-34==
==Solution structure of the leader sequence of the patellamide precursor peptide, PatE1-34==
<StructureSection load='2kya' size='340' side='right'caption='[[2kya]], [[NMR_Ensembles_of_Models | 14 NMR models]]' scene=''>
<StructureSection load='2kya' size='340' side='right'caption='[[2kya]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2kya]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KYA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KYA FirstGlance]. <br>
<table><tr><td colspan='2'>[[2kya]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Prochloron_didemni Prochloron didemni]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KYA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KYA FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kya OCA], [https://pdbe.org/2kya PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kya RCSB], [https://www.ebi.ac.uk/pdbsum/2kya PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kya ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kya OCA], [https://pdbe.org/2kya PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kya RCSB], [https://www.ebi.ac.uk/pdbsum/2kya PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kya ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q52QJ3_PRODI Q52QJ3_PRODI]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kya ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kya ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The solution structure of the leader sequence of the patellamide precursor peptide was analysed by using CD and determined with NOE-restrained molecular dynamics calculations. This leader sequence is highly conserved in the precursor peptides of some other cyanobactins harbouring heterocycles, and is assumed to play a role in targeting the precursor peptide to the post-translational machinery. The sequence was observed to form an alpha-helix spanning residues 13-28 with a hydrophobic surface on one side of the helix. This hydrophobic surface is proposed to be the site of the initial binding with modifying enzymes.
Solution Structure of the Leader Sequence of the Patellamide Precursor Peptide, PatE(1-34).,Houssen WE, Wright SH, Kalverda AP, Thompson GS, Kelly SM, Jaspars M Chembiochem. 2010 Aug 16. PMID:20715266<ref>PMID:20715266</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2kya" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Houssen, W E]]
[[Category: Prochloron didemni]]
[[Category: Jaspars, M]]
[[Category: Houssen WE]]
[[Category: Kalverda, A P]]
[[Category: Jaspars M]]
[[Category: Kelly, S M]]
[[Category: Kalverda AP]]
[[Category: Thompson, G S]]
[[Category: Kelly SM]]
[[Category: Wright, S H]]
[[Category: Thompson GS]]
[[Category: Cyclic peptide]]
[[Category: Wright SH]]
[[Category: Pate]]
[[Category: Patellamide]]
[[Category: Prochloron]]
[[Category: Ribosomal peptide synthetase]]
[[Category: Unknown function]]

Latest revision as of 06:50, 1 May 2024

Solution structure of the leader sequence of the patellamide precursor peptide, PatE1-34

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