2xa6: Difference between revisions
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==Structural basis for homodimerization of the Src-associated during mitosis, 68 kD protein (Sam68) Qua1 domain== | ==Structural basis for homodimerization of the Src-associated during mitosis, 68 kD protein (Sam68) Qua1 domain== | ||
<StructureSection load='2xa6' size='340' side='right'caption='[[2xa6 | <StructureSection load='2xa6' size='340' side='right'caption='[[2xa6]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2xa6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2xa6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XA6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XA6 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xa6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xa6 OCA], [https://pdbe.org/2xa6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xa6 RCSB], [https://www.ebi.ac.uk/pdbsum/2xa6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xa6 ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xa6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xa6 OCA], [https://pdbe.org/2xa6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xa6 RCSB], [https://www.ebi.ac.uk/pdbsum/2xa6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xa6 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/KHDR1_HUMAN KHDR1_HUMAN] Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export.<ref>PMID:9013542</ref> <ref>PMID:9045636</ref> <ref>PMID:11585385</ref> <ref>PMID:1374686</ref> [UniProtKB:Q60749][UniProtKB:Q8UUW7] Isoform 3, which is expressed in growth-arrested cells only, inhibits S phase.<ref>PMID:9013542</ref> <ref>PMID:9045636</ref> <ref>PMID:11585385</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Brack-Werner | [[Category: Brack-Werner R]] | ||
[[Category: Kateb | [[Category: Kateb F]] | ||
[[Category: Madl | [[Category: Madl T]] | ||
[[Category: Meyer | [[Category: Meyer NH]] | ||
[[Category: Sattler | [[Category: Sattler M]] | ||
[[Category: Tripsianes | [[Category: Tripsianes K]] | ||
[[Category: Vincendeaux | [[Category: Vincendeaux M]] | ||
