2xik: Difference between revisions
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<StructureSection load='2xik' size='340' side='right'caption='[[2xik]], [[Resolution|resolution]] 1.97Å' scene=''> | <StructureSection load='2xik' size='340' side='right'caption='[[2xik]], [[Resolution|resolution]] 1.97Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2xik]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2xik]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XIK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XIK FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=J60:5-[(E)-(5-CHLORO-2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]-N-[2-(DIETHYLAMINO)ETHYL]-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXAMIDE'>J60</scene> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.97Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=J60:5-[(E)-(5-CHLORO-2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]-N-[2-(DIETHYLAMINO)ETHYL]-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXAMIDE'>J60</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xik FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xik OCA], [https://pdbe.org/2xik PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xik RCSB], [https://www.ebi.ac.uk/pdbsum/2xik PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xik ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xik FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xik OCA], [https://pdbe.org/2xik PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xik RCSB], [https://www.ebi.ac.uk/pdbsum/2xik PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xik ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/STK25_HUMAN STK25_HUMAN] Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration.<ref>PMID:15037601</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xi/2xik_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xi/2xik_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Allerston C]] | |||
[[Category: Allerston | [[Category: Arrowsmith CH]] | ||
[[Category: Arrowsmith | [[Category: Berridge G]] | ||
[[Category: Berridge | [[Category: Bountra C]] | ||
[[Category: Bountra | [[Category: Brenner B]] | ||
[[Category: Brenner | [[Category: Chaikuad A]] | ||
[[Category: Chaikuad | [[Category: Daga N]] | ||
[[Category: Daga | [[Category: Edwards AM]] | ||
[[Category: Elkins JM]] | |||
[[Category: Edwards | [[Category: Gileadi O]] | ||
[[Category: Elkins | [[Category: Knapp S]] | ||
[[Category: Gileadi | [[Category: Mahajan P]] | ||
[[Category: Knapp | [[Category: Muniz JRC]] | ||
[[Category: Mahajan | [[Category: Rellos P]] | ||
[[Category: Muniz | [[Category: Savitsky P]] | ||
[[Category: Rellos | [[Category: Shrestha B]] | ||
[[Category: Savitsky | [[Category: Ugochukwu E]] | ||
[[Category: Shrestha | [[Category: Vollmar M]] | ||
[[Category: Ugochukwu | [[Category: Weigelt J]] | ||
[[Category: Vollmar | [[Category: Von Delft F]] | ||
[[Category: Weigelt | |||
[[Category: | |||
