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| {{STRUCTURE_1fpv| PDB=1fpv | SCENE= }} | | {{STRUCTURE_1fpv| PDB=1fpv | SCENE= }} |
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| '''STRUCTURE DETERMINATION OF FELINE PANLEUKOPENIA VIRUS EMPTY PARTICLES'''
| | ===STRUCTURE DETERMINATION OF FELINE PANLEUKOPENIA VIRUS EMPTY PARTICLES=== |
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| ==Overview==
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| Various crystal forms of the single-stranded DNA, feline panleukopenia virus (FPV), a parvovirus, have been grown of both full virions and empty particles. The structure of empty particles crystallized in an orthorhombic space group P2(1)2(1)2(1), with unit cell dimensions a = 380.1 A, b = 379.3 A, and c = 350.9 A, has been determined to 3.3 A resolution. The data were collected using oscillation photography with synchrotron radiation. The orientations of the empty capsids in the unit cell were determined using a self-rotation function and their positions were obtained with an R-factor search using canine parvovirus (CPV) as a model. Phases were then calculated, based on the CPV model, to 6.0 A resolution and gradually extended to 3.3 A resolution by molecular replacement electron density averaging. The resultant electron density was readily interpreted in terms of the known amino acid sequence. The structure is contrasted to that of CPV in terms of host range, neutralization by antibodies, hemagglutination properties, and binding of genomic DNA.
| | The line below this paragraph, {{ABSTRACT_PUBMED_8392729}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 8392729 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_8392729}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Icosahedral virus]] | | [[Category: Icosahedral virus]] |
| [[Category: Panleukemia virus coat protein]] | | [[Category: Panleukemia virus coat protein]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:37:29 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:45:16 2008'' |
