1fq9: Difference between revisions

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[[Image:1fq9.jpg|left|200px]]
{{Seed}}
[[Image:1fq9.png|left|200px]]


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{{STRUCTURE_1fq9|  PDB=1fq9  |  SCENE=  }}  
{{STRUCTURE_1fq9|  PDB=1fq9  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF A TERNARY FGF2-FGFR1-HEPARIN COMPLEX'''
===CRYSTAL STRUCTURE OF A TERNARY FGF2-FGFR1-HEPARIN COMPLEX===




==Overview==
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The crystal structure of a dimeric 2:2:2 FGF:FGFR:heparin ternary complex at 3 A resolution has been determined. Within each 1:1 FGF:FGFR complex, heparin makes numerous contacts with both FGF and FGFR, thereby augmenting FGF-FGFR binding. Heparin also interacts with FGFR in the adjoining 1:1 FGF:FGFR complex to promote FGFR dimerization. The 6-O-sulfate group of heparin plays a pivotal role in mediating both interactions. The unexpected stoichiometry of heparin binding in the structure led us to propose a revised model for FGFR dimerization. Biochemical data in support of this model are also presented. This model provides a structural basis for FGFR activation by small molecule heparin analogs and may facilitate the design of heparin mimetics capable of modulating FGF signaling.
The line below this paragraph, {{ABSTRACT_PUBMED_11030354}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_11030354}}


==About this Structure==
==About this Structure==
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[[Category: B-trefoil fold]]
[[Category: B-trefoil fold]]
[[Category: I-set subgroup within the immunoglobulin superfamily]]
[[Category: I-set subgroup within the immunoglobulin superfamily]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:38:20 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:46:26 2008''

Revision as of 00:46, 1 July 2008

File:1fq9.png

Template:STRUCTURE 1fq9

CRYSTAL STRUCTURE OF A TERNARY FGF2-FGFR1-HEPARIN COMPLEX

Template:ABSTRACT PUBMED 11030354

About this Structure

1FQ9 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization., Schlessinger J, Plotnikov AN, Ibrahimi OA, Eliseenkova AV, Yeh BK, Yayon A, Linhardt RJ, Mohammadi M, Mol Cell. 2000 Sep;6(3):743-50. PMID:11030354

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