2xsn: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
 
Line 3: Line 3:
<StructureSection load='2xsn' size='340' side='right'caption='[[2xsn]], [[Resolution|resolution]] 2.68&Aring;' scene=''>
<StructureSection load='2xsn' size='340' side='right'caption='[[2xsn]], [[Resolution|resolution]] 2.68&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2xsn]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XSN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XSN FirstGlance]. <br>
<table><tr><td colspan='2'>[[2xsn]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XSN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XSN FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.68&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Tyrosine_3-monooxygenase Tyrosine 3-monooxygenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.16.2 1.14.16.2] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xsn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xsn OCA], [https://pdbe.org/2xsn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xsn RCSB], [https://www.ebi.ac.uk/pdbsum/2xsn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xsn ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xsn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xsn OCA], [https://pdbe.org/2xsn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xsn RCSB], [https://www.ebi.ac.uk/pdbsum/2xsn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xsn ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[https://www.uniprot.org/uniprot/TY3H_HUMAN TY3H_HUMAN]] Autosomal recessive dopa-responsive dystonia. The disease is caused by mutations affecting the gene represented in this entry.  May play a role in the pathogenesis of Parkinson disease (PD). A genome-wide copy number variation analysis has identified a 34 kilobase deletion over the TH gene in a PD patient but not in any controls.<ref>PMID:20809526</ref>
[https://www.uniprot.org/uniprot/TY3H_HUMAN TY3H_HUMAN] Autosomal recessive dopa-responsive dystonia. The disease is caused by mutations affecting the gene represented in this entry.  May play a role in the pathogenesis of Parkinson disease (PD). A genome-wide copy number variation analysis has identified a 34 kilobase deletion over the TH gene in a PD patient but not in any controls.<ref>PMID:20809526</ref>  
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/TY3H_HUMAN TY3H_HUMAN]] Plays an important role in the physiology of adrenergic neurons.  
[https://www.uniprot.org/uniprot/TY3H_HUMAN TY3H_HUMAN] Plays an important role in the physiology of adrenergic neurons.


==See Also==
==See Also==
Line 20: Line 20:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Tyrosine 3-monooxygenase]]
[[Category: Arrowsmith CH]]
[[Category: Arrowsmith, C H]]
[[Category: Bountra C]]
[[Category: Bountra, C]]
[[Category: Cooper CDO]]
[[Category: Cooper, C D.O]]
[[Category: Edwards AM]]
[[Category: Delft, F von]]
[[Category: Gileadi O]]
[[Category: Edwards, A M]]
[[Category: Kavanagh KL]]
[[Category: Gileadi, O]]
[[Category: Knapp S]]
[[Category: Kavanagh, K L]]
[[Category: Krysztofinska E]]
[[Category: Knapp, S]]
[[Category: Muniz JRC]]
[[Category: Krysztofinska, E]]
[[Category: Oppermann U]]
[[Category: Muniz, J R.C]]
[[Category: Weigelt J]]
[[Category: Oppermann, U]]
[[Category: Yue WW]]
[[Category: Weigelt, J]]
[[Category: Von Delft F]]
[[Category: Yue, W W]]
[[Category: Oxidoreductase]]
Retrieved from "https://proteopedia.org/2xsn"