7rx8: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 7rx8 is ~~ON HOLD until Paper Publication~~

==Structure of METTL3-METTL14(R298H) mutant methyltransferase complex==

~~Authors~~: ~~Wang~~, P., ~~Nam~~, Y.

== Structural highlights ==

<table><tr><td colspan='2'>[[7rx8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RX8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RX8 FirstGlance]. <br>

~~Description~~: ~~Structure~~ of ~~METTL3~~-~~METTL14~~(~~R298H~~) ~~mutant methyltransferase complex~~

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rx8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rx8 OCA], [https://pdbe.org/7rx8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rx8 RCSB], [https://www.ebi.ac.uk/pdbsum/7rx8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rx8 ProSAT]</span></td></tr>

[[Category: ~~Unreleased Structures~~]]

</table>

[[Category: ~~Wang, P~~]]

== Function ==

[[Category: Nam, Y]]

[https://www.uniprot.org/uniprot/MTA70_HUMAN MTA70_HUMAN] N6-methyltransferase that methylates adenosine residues of some RNAs and acts as a regulator of the circadian clock, differentiation of embryonic stem cells and primary miRNA processing. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in the efficiency of mRNA splicing, processing, translation efficiency, editing and mRNA stability (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:9409616). M6A regulates the length of the circadian clock: acts as a early pace-setter in the circadian loop by putting mRNA production on a fast-track for facilitating nuclear processing, thereby providing an early point of control in setting the dynamics of the feedback loop (By similarity). M6A also acts as a regulator of mRNA stability: in embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization, promoting differentiation of ESCs (By similarity). M6A also takes place in other RNA molecules, such as primary miRNA (pri-miRNAs) (PubMed:25799998). Mediates methylation of pri-miRNAs, marking them for recognition and processing by DGCR8 (PubMed:25799998).[UniProtKB:Q8C3P7]<ref>PMID:22575960</ref> <ref>PMID:24284625</ref> <ref>PMID:25719671</ref> <ref>PMID:25799998</ref> <ref>PMID:26321680</ref> <ref>PMID:26593424</ref> <ref>PMID:9409616</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Nam Y]]

[[Category: Wang P]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 7rx8 is ON HOLD  until Paper Publication
+==Structure of METTL3-METTL14(R298H) mutant methyltransferase complex==
+<StructureSection load='7rx8' size='340' side='right'caption='[[7rx8]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
-Authors: Wang, P., Nam, Y.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7rx8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RX8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RX8 FirstGlance]. <br>
-Description: Structure of METTL3-METTL14(R298H) mutant methyltransferase complex
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rx8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rx8 OCA], [https://pdbe.org/7rx8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rx8 RCSB], [https://www.ebi.ac.uk/pdbsum/7rx8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rx8 ProSAT]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
-[[Category: Wang, P]]
+== Function ==
-[[Category: Nam, Y]]
+[https://www.uniprot.org/uniprot/MTA70_HUMAN MTA70_HUMAN] N6-methyltransferase that methylates adenosine residues of some RNAs and acts as a regulator of the circadian clock, differentiation of embryonic stem cells and primary miRNA processing. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in the efficiency of mRNA splicing, processing, translation efficiency, editing and mRNA stability (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:9409616). M6A regulates the length of the circadian clock: acts as a early pace-setter in the circadian loop by putting mRNA production on a fast-track for facilitating nuclear processing, thereby providing an early point of control in setting the dynamics of the feedback loop (By similarity). M6A also acts as a regulator of mRNA stability: in embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization, promoting differentiation of ESCs (By similarity). M6A also takes place in other RNA molecules, such as primary miRNA (pri-miRNAs) (PubMed:25799998). Mediates methylation of pri-miRNAs, marking them for recognition and processing by DGCR8 (PubMed:25799998).[UniProtKB:Q8C3P7]<ref>PMID:22575960</ref> <ref>PMID:24284625</ref> <ref>PMID:25719671</ref> <ref>PMID:25799998</ref> <ref>PMID:26321680</ref> <ref>PMID:26593424</ref> <ref>PMID:9409616</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Nam Y]]
+[[Category: Wang P]]