2bvg: Difference between revisions

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<StructureSection load='2bvg' size='340' side='right'caption='[[2bvg]], [[Resolution|resolution]] 3.18&Aring;' scene=''>
<StructureSection load='2bvg' size='340' side='right'caption='[[2bvg]], [[Resolution|resolution]] 3.18&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2bvg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_49919 Atcc 49919]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BVG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BVG FirstGlance]. <br>
<table><tr><td colspan='2'>[[2bvg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Paenarthrobacter_nicotinovorans Paenarthrobacter nicotinovorans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BVG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BVG FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.18&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2bvf|2bvf]], [[2bvh|2bvh]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/(R)-6-hydroxynicotine_oxidase (R)-6-hydroxynicotine oxidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.3.6 1.5.3.6] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bvg OCA], [https://pdbe.org/2bvg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bvg RCSB], [https://www.ebi.ac.uk/pdbsum/2bvg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bvg ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bvg OCA], [https://pdbe.org/2bvg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bvg RCSB], [https://www.ebi.ac.uk/pdbsum/2bvg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bvg ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HDNO_PAENI HDNO_PAENI] Involved in the degradation of D-nicotine (PubMed:5849820, PubMed:4628374). Catalyzes the oxidation of (R)-6-hydroxynicotine (6-hydroxy-D-nicotine) to 6-hydroxypseudooxynicotine (PubMed:5849820, PubMed:4965794, PubMed:4628374, PubMed:2680607, PubMed:31046245). Oxidation of the pyrrolidine ring of (R)-6-hydroxynicotine leads to the formation of the optically inactive 6-hydroxy-N-methylmyosmine, which hydrolyzes spontaneously to 6-hydroxypseudooxynicotine (PubMed:4965794, PubMed:4628374, PubMed:31046245). Acts with absolute stereospecificity on the D-form of 6-hydroxynicotine (PubMed:4965794, PubMed:4628374). Shows lower activity with (R)-6-hydroxynornicotine, and weak activity with (R)-4-(1-methylpyrrolidine-2-yl)phenol, (R)-6-chloronicotine and (R)-nicotine (PubMed:31046245).<ref>PMID:2680607</ref> <ref>PMID:31046245</ref> <ref>PMID:4628374</ref> <ref>PMID:4965794</ref> <ref>PMID:5849820</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Atcc 49919]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Koetter, J W.A]]
[[Category: Paenarthrobacter nicotinovorans]]
[[Category: Schulz, G E]]
[[Category: Koetter JWA]]
[[Category: Autoflavinylation]]
[[Category: Schulz GE]]
[[Category: Enantiomeric substrate]]
[[Category: Flavoenzyme]]
[[Category: Nicotine degradation]]
[[Category: Oxidase]]
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