2jx2: Difference between revisions
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==Solution conformation of RNA-bound NELF-E RRM== | ==Solution conformation of RNA-bound NELF-E RRM== | ||
<StructureSection load='2jx2' size='340' side='right'caption='[[2jx2 | <StructureSection load='2jx2' size='340' side='right'caption='[[2jx2]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2jx2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2jx2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JX2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JX2 FirstGlance]. <br> | ||
</td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jx2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jx2 OCA], [https://pdbe.org/2jx2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jx2 RCSB], [https://www.ebi.ac.uk/pdbsum/2jx2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jx2 ProSAT]</span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jx2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jx2 OCA], [https://pdbe.org/2jx2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jx2 RCSB], [https://www.ebi.ac.uk/pdbsum/2jx2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jx2 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/NELFE_HUMAN NELFE_HUMAN] Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex.<ref>PMID:10199401</ref> <ref>PMID:11940650</ref> <ref>PMID:12612062</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Jampani | [[Category: Jampani N]] | ||
[[Category: Roesch | [[Category: Roesch P]] | ||
[[Category: Schweimer | [[Category: Schweimer K]] | ||
[[Category: Wenzel | [[Category: Wenzel S]] | ||
[[Category: Woehrl | [[Category: Woehrl BM]] | ||
