NS5B: Difference between revisions

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==RNA Dependent RNA Polymerase from Hepatitis C Virus==

In 2019, there were approximately 290,000 deaths due to a Hepatitis C infection. The majority of these deaths were largely due to the long-term adverse effects such as cirrhosis and liver cancer. Currently in the world, about 58 million people are chronically infected with the Hepatitis C virus and there are about 1.5 million new infections annually. In the United States, data estimates that 2.4 million people are infected with Hepatitis C. Due to the low percentage of diagnoses and the frequency of acute infection, it is believed that the number of Hepatitis C infections can range anywhere from 2.5 million to 4.7 million infected individuals. Nearly all of RNA viruses depend on specific activities performed by RNA dependent RNA polymerases (RdRp). These activities importantly include the copying of the RNA sequence and facilitating the process of transcription. Therefore, if a vaccine was created to target the RNA dependent RNA polymerase and inhibit the function of this protein, then the viral genome could not be replicated. If replication halts, the infection cannot spread to other cells. Due to the viral dependence on RdRps, it is essential to understand the structure for further antiviral drug research.

In 2019, there were approximately 290,000 deaths due to a Hepatitis C infection. The majority of these deaths were largely due to the long-term adverse effects such as cirrhosis and liver cancer. Currently in the world, about 58 million people are chronically infected with the Hepatitis C virus and there are about 1.5 million new infections annually. In the United States, data estimates that 2.4 million people are infected with Hepatitis C. Due to the low percentage of diagnoses and the frequency of acute infection, it is believed that the number of Hepatitis C infections can range anywhere from 2.5 million to 4.7 million infected individuals. Nearly all of RNA viruses depend on specific activities performed by RNA dependent RNA polymerases (RdRp). These activities importantly include the copying of the RNA sequence and facilitating the process of transcription. Therefore, if a vaccine was created to target the RNA dependent RNA polymerase and inhibit the function of this protein, then the viral genome could not be replicated. If replication halts, the infection cannot spread to other cells. Due to the viral dependence on RdRps, it is essential to understand the structure for further antiviral drug research. [[Sofosbuvir]] is an inhibitor of NS5B used for Hepatitis C treatment.

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Revision as of 02:43, 29 November 2021 view source Kody Witham (talk \| contribs) 42 edits No edit summary ← Older edit		Latest revision as of 10:20, 21 January 2024 view source Michal Harel (talk \| contribs) 32,826 edits No edit summary
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	==RNA Dependent RNA Polymerase from Hepatitis C Virus==		==RNA Dependent RNA Polymerase from Hepatitis C Virus==

	In 2019, there were approximately 290,000 deaths due to a Hepatitis C infection. The majority of these deaths were largely due to the long-term adverse effects such as cirrhosis and liver cancer. Currently in the world, about 58 million people are chronically infected with the Hepatitis C virus and there are about 1.5 million new infections annually. In the United States, data estimates that 2.4 million people are infected with Hepatitis C. Due to the low percentage of diagnoses and the frequency of acute infection, it is believed that the number of Hepatitis C infections can range anywhere from 2.5 million to 4.7 million infected individuals. Nearly all of RNA viruses depend on specific activities performed by RNA dependent RNA polymerases (RdRp). These activities importantly include the copying of the RNA sequence and facilitating the process of transcription. Therefore, if a vaccine was created to target the RNA dependent RNA polymerase and inhibit the function of this protein, then the viral genome could not be replicated. If replication halts, the infection cannot spread to other cells. Due to the viral dependence on RdRps, it is essential to understand the structure for further antiviral drug research.		In 2019, there were approximately 290,000 deaths due to a Hepatitis C infection. The majority of these deaths were largely due to the long-term adverse effects such as cirrhosis and liver cancer. Currently in the world, about 58 million people are chronically infected with the Hepatitis C virus and there are about 1.5 million new infections annually. In the United States, data estimates that 2.4 million people are infected with Hepatitis C. Due to the low percentage of diagnoses and the frequency of acute infection, it is believed that the number of Hepatitis C infections can range anywhere from 2.5 million to 4.7 million infected individuals. Nearly all of RNA viruses depend on specific activities performed by RNA dependent RNA polymerases (RdRp). These activities importantly include the copying of the RNA sequence and facilitating the process of transcription. Therefore, if a vaccine was created to target the RNA dependent RNA polymerase and inhibit the function of this protein, then the viral genome could not be replicated. If replication halts, the infection cannot spread to other cells. Due to the viral dependence on RdRps, it is essential to understand the structure for further antiviral drug research. [[Sofosbuvir]] is an inhibitor of NS5B used for Hepatitis C treatment.