1ft9: Difference between revisions

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[[Image:1ft9.~~jpg~~|left|200px]]

[[Image:1ft9.png|left|200px]]

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~~'''~~STRUCTURE OF THE REDUCED (FEII) CO-SENSING PROTEIN FROM R. RUBRUM~~'''~~

===STRUCTURE OF THE REDUCED (FEII) CO-SENSING PROTEIN FROM R. RUBRUM===

~~==Overview==~~

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~~CooA is a homodimeric transcription factor that belongs~~ to the ~~catabolite activator protein~~ (~~CAP) family. Binding of CO to the heme groups of CooA leads to the transcription of genes involved in CO oxidation in Rhodospirillum rubrum~~. ~~The 2~~.~~6 A structure of reduced (Fe2+~~) ~~CooA reveals that His 77 in both subunits provides one heme ligand while~~ the N-terminal nitrogen of Pro 2 from the opposite subunit provides the other ligand. A structural comparison of CooA in the absence of effector and DNA (off state) with that of CAP in the effector and DNA bound state (on state) leads to a plausible model for the mechanism of allosteric control in this class of proteins as well as the CO dependent activation of CooA.

The line below this paragraph, {{ABSTRACT_PUBMED_11017196}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 11017196 is the PubMed ID number.

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==About this Structure==

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[[Category: Catabolite gene activator protein]]

[[Category: Heme sensor]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ ~~2 16~~:44:28 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:54:55 2008''

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-[[Image:1ft9.jpg|left|200px]]
+{{Seed}}
+[[Image:1ft9.png|left|200px]]
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 {{STRUCTURE_1ft9|  PDB=1ft9  |  SCENE=  }}
-'''STRUCTURE OF THE REDUCED (FEII) CO-SENSING PROTEIN FROM R. RUBRUM'''
+===STRUCTURE OF THE REDUCED (FEII) CO-SENSING PROTEIN FROM R. RUBRUM===
-==Overview==
+<!--
-CooA is a homodimeric transcription factor that belongs to the catabolite activator protein (CAP) family. Binding of CO to the heme groups of CooA leads to the transcription of genes involved in CO oxidation in Rhodospirillum rubrum. The 2.6 A structure of reduced (Fe2+) CooA reveals that His 77 in both subunits provides one heme ligand while the N-terminal nitrogen of Pro 2 from the opposite subunit provides the other ligand. A structural comparison of CooA in the absence of effector and DNA (off state) with that of CAP in the effector and DNA bound state (on state) leads to a plausible model for the mechanism of allosteric control in this class of proteins as well as the CO dependent activation of CooA.
+The line below this paragraph, {{ABSTRACT_PUBMED_11017196}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 11017196 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_11017196}}
 ==About this Structure==
@@ Line 31: / Line 35: @@
 [[Category: Catabolite gene activator protein]]
 [[Category: Heme sensor]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 16:44:28 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 03:54:55 2008''