2ch6: Difference between revisions

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<StructureSection load='2ch6' size='340' side='right'caption='[[2ch6]], [[Resolution|resolution]] 2.72&Aring;' scene=''>
<StructureSection load='2ch6' size='340' side='right'caption='[[2ch6]], [[Resolution|resolution]] 2.72&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2ch6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CH6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CH6 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2ch6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CH6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CH6 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.72&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2ch5|2ch5]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/N-acetylglucosamine_kinase N-acetylglucosamine kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.59 2.7.1.59] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ch6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ch6 OCA], [https://pdbe.org/2ch6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ch6 RCSB], [https://www.ebi.ac.uk/pdbsum/2ch6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ch6 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ch6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ch6 OCA], [https://pdbe.org/2ch6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ch6 RCSB], [https://www.ebi.ac.uk/pdbsum/2ch6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ch6 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/NAGK_HUMAN NAGK_HUMAN]] Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded. Also has ManNAc kinase activity.<ref>PMID:22692205</ref>
[https://www.uniprot.org/uniprot/NAGK_HUMAN NAGK_HUMAN] Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded. Also has ManNAc kinase activity.<ref>PMID:22692205</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: N-acetylglucosamine kinase]]
[[Category: Berger M]]
[[Category: Berger, M]]
[[Category: Chen H]]
[[Category: Chen, H]]
[[Category: Hinderlich S]]
[[Category: Hinderlich, S]]
[[Category: Saenger W]]
[[Category: Saenger, W]]
[[Category: Weihofen WA]]
[[Category: Weihofen, W A]]
[[Category: Ribonuclease h fold]]
[[Category: Sugar kinase]]
[[Category: Sugar kinase/hsp70/actin superfamily]]
[[Category: Transferase]]
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